Dual specificity mitogen-activated protein kinase kinase 1 is a protein in humans that is encoded by MAP2K1 gene. Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade.

MAP2K1 Antibodies

MAP2K1 Antibodies for Homo sapiens (Human)

MAP2K1 Proteins

MAP2K1 Proteins for Mus musculus (Mouse)

MAP2K1 Proteins for Oryctolagus cuniculus (Rabbit)

MAP2K1 Proteins for Rattus norvegicus (Rat)

MAP2K1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

MAP2K1 Proteins for Serinus canaria (Island canary) (Fringilla canaria)

MAP2K1 Proteins for Pan troglodytes (Chimpanzee)


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