Code | CSB-RA013409A292phHU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
CUSABIO designed the vector clones for the expression of a recombinant MAP2K1 antibody in mammalian cells. The vector clones were obtained by inserting the MAP2K1 antibody heavy and light chains into the plasma vectors. The recombinant MAP2K1 antibody was purified from the culture medium through affinity-chromatography. It can be used to detect MAP2K1 protein from Human in the ELISA, WB.
The phospho-MAP2K1 (T292) antibody can detect the MAP2K1 only when phosphorylated at T292. MAP2K1, also called MEK1, functions immediately upstream of MAPK in the MAPK signaling pathway. Phosphorylation of T292 on MAP2K1 by activated ERK is required for the formation of ternary complex PTEN/MAGI1/MAP2K1. MAP2K1 mutations have been found in several human malignancies, particularly melanoma, hairy cell leukemia, and lung adenocarcinoma.
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