NAMPT

NAMPT, nicotinamide phosphoribosyltransferase, alias PBEF, Visfatin, pre-B-cell colony-enhancing factor and so on. It is a multifunctional protein encoded by the NAMPT gene, which is mainly expressed in a variety of tissues, such as brown adipose tissue, liver, kidney, etc., especially in adipose tissue.The mechanism of action of NAMPT mainly catalyzes the synthesis of nicotinamide mononucleotide (NMN) from nicotinamide (NAM) and 5'-phosphoribose pyrophosphate (PRPP), which is the remedial pathway of NAD+ synthesis This is the first and rate-limiting step of the remedial pathway for NAD+ synthesis.

NAMPT has a wide range of biological significance, not only does it play a key role in intracellular NAD+ synthesis and energy metabolism, but also participates in the regulation of a variety of physiological and pathological processes in the form of secreted eNAMPT. eNAMPT possesses cytokine-like activity, promotes inflammation and angiogenesis, and is closely associated with tumorigenesis, progression, and metastasis. In addition, the expression level of NAMPT changes in a variety of age-related diseases such as metabolic diseases, neurodegenerative diseases, aging and cancer, suggesting that it may play an important role in these diseases . Therefore, NAMPT is a potential target in drug development and disease treatment, and activators and inhibitors against NAMPT are being investigated for the treatment of related diseases.