PRF1 Research Reagents

Perforin-1 is a protein in humans that is encoded by PRF1 gene. Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.

The following PRF1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PRF1 Antibodies

PRF1 Antibodies for Homo sapiens (Human)

PRF1 Antibodies for Mus musculus (Mouse)

PRF1 Antibodies for Rattus norvegicus (Rat)

PRF1 Proteins

PRF1 Proteins for Mus musculus (Mouse)

PRF1 Proteins for Homo sapiens (Human)

PRF1 Proteins for Rattus norvegicus (Rat)

PRF1 Proteins for Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)

PRF1 Proteins for Methanococcus maripaludis (strain S2 / LL)

PRF1 Proteins for Methanococcus maripaludis (strain C5 / ATCC BAA-1333)

PRF1 Proteins for Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)

PRF1 Proteins for Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)

PRF1 Proteins for Methanococcus maripaludis (strain C7 / ATCC BAA-1331)

PRF1 Proteins for Methanococcus maripaludis (strain C6 / ATCC BAA-1332)

PRF1 Proteins for Thermococcus onnurineus (strain NA1)

PRF1 Proteins for Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)

PRF1 Proteins for Thermococcus sibiricus (strain MM 739 / DSM 12597)

PRF1 Proteins for Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

PRF1 Proteins for Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)

PRF1 Proteins for Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)

PRF1 Proteins for Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)

PRF1 Proteins for Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)

PRF1 Proteins for Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)

PRF1 Proteins for Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)

PRF1 Proteins for Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))

PRF1 Proteins for Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

PRF1 Proteins for Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)

PRF1 Proteins for Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)

PRF1 Proteins for Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)

PRF1 Proteins for Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

PRF1 Proteins for Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)

PRF1 Proteins for Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

PRF1 Proteins for Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)

PRF1 Proteins for Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

PRF1 Proteins for Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)

PRF1 Proteins for Pyrococcus abyssi (strain GE5 / Orsay)


PRF1 ELISA Kit for Homo sapiens (Human)

PRF1 ELISA Kit for Mus musculus (Mouse)

PRF1 Background

The PRF1 gene encodes perforin [1][2]. Perforin is found in immune cells (lymphocytes) called T cells and natural killer (NK) cells, which destroy other cells. Perforin is involved in the process of cell destruction (cytolysis) and the regulation of the immune system. Perforin is a major component of structures called cytolytic granules within T cells and NK cells. One of the main ways in which T cells and NK cells destroy other cells is to transport and secrete these cytolytic granules, which contain cell-killing proteins, onto the membranes of the target cells. Perforin helps create a channel through the membrane, allowing cytolytic proteins to enter the cell and trigger it to self-destruct. This cytolytic mechanism also helps regulate the immune system by destroying unneeded T cells. Controlling the number of T cells prevents the overproduction of immune proteins called cytokines that lead to inflammation and, in excess, cause tissue damage. It also can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Besides, It promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.

[1] Fink TM, Zimmer M, Weitz S, Tschopp J, Jenne DE, Lichter P (Sep 1992). "Human perforin (PRF1) maps to 10q22, a region that is syntenic with mouse chromosome 10". Genomics. 13 (4): 1300–2.
[2] Shinkai Y, Yoshida MC, Maeda K, Kobata T, Maruyama K, Yodoi J, Yagita H, Okumura K (Jan 1990). "Molecular cloning and chromosomal assignment of a human perforin (PFP) gene". Immunogenetics. 30 (6): 452–7.


Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2021 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1