STAT3, signal transducer and activator of transcription 3, aliases include acute regulatory protein, signal transducer activator, linoleic acid-inducible protein, etc. STAT3 is a transcription factor that is widely found in a variety of cell types and is encoded by genes in human cells themselves. Its mechanism of action is mainly the phosphorylation of activated tyrosine kinases after the cell receives external signals, such as cytokines, growth factors, or other stimuli, to form a dimer, which is subsequently transferred to the nucleus of the cell to regulate the expression of specific genes.The activation of STAT3 involves the signaling pathways such as JAK/STAT, IL-6/STAT3, etc., wherein the Janus kinase (JAK) is first activated and phosphorylates STAT3, leading to its homodimerization and intranuclear translocation.
STAT3 has a wide range of biological significance, which is involved in the regulation of a variety of cellular physiological processes, including cell proliferation, differentiation, migration, apoptosis, and the immune response, etc. The activation of STAT3 is essential for the maintenance of cellular homeostasis and adaptation to external changes. In addition, STAT3 plays a key role in the development of many diseases, especially in tumor development, where the sustained activation of STAT3 is closely related to tumor cell proliferation, survival, angiogenesis and immune escape. Therefore, STAT3 has become an important target in cancer therapy. The regulatory role of STAT3 in autoimmune diseases, inflammatory response and tissue repair should also not be ignored, and intervention strategies targeting STAT3 may provide new avenues for the treatment of these diseases.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
STAT3 Recombinant Monoclonal Antibody (CSB-RA546821A0HU)
Validated Data
Overlay histogram showing Hela cells stained with CSB-RA546821A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1µg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.
The following STAT3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
STAT3 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA022812GA01HU | STAT3 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA954939 | Phospho-STAT3 (Tyr705) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA699573 | Phospho-STAT3 (Ser727) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA088158 | STAT3 (Ab-727) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA586999 | STAT3 (Ab-705) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA000621 | Phospho-STAT3 (S727) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IP, ELISA |
CSB-PA000622 | Phospho-STAT3 (Y705) Antibody | Human, Mouse, Rat | WB, IHC, IP, ELISA |
CSB-PA004173 | STAT3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA004174 | STAT3 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA050164 | STAT3 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
CSB-PA080245 | STAT3 Antibody | Human | WB, IHC |
CSB-PA022812LA01HU | STAT3 Antibody | Human | ELISA, IHC, IF, IP |
CSB-PA022812LB01HU | STAT3 Antibody, HRP conjugated | Human | ELISA |
CSB-PA022812LC01HU | STAT3 Antibody, FITC conjugated | Human | |
CSB-PA022812LD01HU | STAT3 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA022812A727phHU | Phospho-STAT3 (S727) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP |
CSB-RA022812A705phHU | Phospho-STAT3 (Tyr705) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
CSB-RA546821A0HU | STAT3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CSB-RA229700A0HU | STAT3 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
CSB-RA188270A0HU | STAT3 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CSB-RA022812MA1HU | STAT3 Recombinant Monoclonal Antibody | Human | ELISA |
STAT3 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA022812XA01MO | Stat3 Antibody | Mus musculus (Mouse) | ELISA, WB (ensure identification of antigen) |
STAT3 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP022812HU CSB-BP022812HU CSB-MP022812HU CSB-EP022812HU-B |
Recombinant Human Signal transducer and activator of transcription 3 (STAT3), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP022812HU | Recombinant Human Signal transducer and activator of transcription 3 (STAT3), partial | E.coli |
CSB-YP022812HU(A4) | Recombinant Human Signal transducer and activator of transcription 3 (STAT3) | Yeast |
CSB-EP022812HU(A4) | Recombinant Human Signal transducer and activator of transcription 3 (STAT3) | E.coli |
CSB-EP022812HU(A4)-B | Recombinant Human Signal transducer and activator of transcription 3 (STAT3),Biotinylated | E.coli |
CSB-EP022812HU2 | Recombinant Human Signal transducer and activator of transcription 3 (STAT3), partial | E.coli |
STAT3 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP022812MO CSB-EP022812MO CSB-BP022812MO CSB-MP022812MO CSB-EP022812MO-B |
Recombinant Mouse Signal transducer and activator of transcription 3 (Stat3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT3 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP022812RA CSB-EP022812RA CSB-BP022812RA CSB-MP022812RA CSB-EP022812RA-B |
Recombinant Rat Signal transducer and activator of transcription 3 (Stat3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT3 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP022812BO CSB-EP022812BO CSB-BP022812BO CSB-MP022812BO CSB-EP022812BO-B |
Recombinant Bovine Signal transducer and activator of transcription 3 (STAT3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT3 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP624331PI CSB-EP624331PI CSB-BP624331PI CSB-MP624331PI CSB-EP624331PI-B |
Recombinant Pig Signal transducer and activator of transcription 3 (STAT3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT3 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP728573CH CSB-EP728573CH CSB-BP728573CH CSB-MP728573CH CSB-EP728573CH-B |
Recombinant Chicken Signal transducer and activator of transcription 3 (STAT3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |