STAT3

STAT3 (Signal Transducer and Activator of Transcription 3) is a signal transduction and transcription activation factor. It participates in cellular signaling pathways and regulates gene transcription within the cell nucleus. When cells are exposed to specific signaling cues such as cytokines, growth factors, or activated receptors, STAT3 becomes phosphorylated and forms dimers or multimers. These phosphorylated STAT3 complexes translocate to the cell nucleus and bind to specific promoter regions of target genes, thereby modulating the transcription levels of these genes. The activation of STAT3 is closely associated with numerous biological processes, including cell proliferation, cell survival, and immune responses. Research on STAT3 contributes to a deeper understanding of cellular signal transduction and gene regulation mechanisms, offering potential novel therapeutic strategies for related diseases.

Popular Product

● STAT3 Recombinant Monoclonal Antibody CSB-RA022812MA1HU

Validated Data

ELISA

The Binding Activity of Human STAT3 with Anti-STAT3 Recombinant Antibody

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human STAT3 (CSB-BP022812HU(A4)j7) at 2 μg/mL can bind Anti-STAT3 recombinant antibody , the EC₅₀ is 41.31-75.59 ng/mL