Recombinant Rat Signal transducer and activator of transcription 3(Stat3)

Code CSB-YP022812RA
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Source Yeast
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Code CSB-EP022812RA
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Source E.coli
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Code CSB-EP022812RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP022812RA
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Source Baculovirus
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Code CSB-MP022812RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Stat3
Uniprot No. P52631
Alternative Names Stat3; Signal transducer and activator of transcription 3
Species Rattus norvegicus (Rat)
Expression Region 1-770
Target Protein Sequence MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ HRPMLEERIV DLFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDMD LTSECATSPM
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G.
Gene References into Functions
  1. Regarding all the findings, it was deduced that STAT3 is one of the active factors in glomerular pathologies. PMID: 30054017
  2. Results revealed Stat3 is a new target of miR-125b-5p and revealed the mechanism of miR-125b-5p suppressing HypoT development. PMID: 30027933
  3. his study demonstrates that postoperative resveratrol administration efficiently improves the prognosis of rat advanced orthotopic glioblastoma via inhibition of growth, induction of apoptosis and inactivation of STAT3 signalling PMID: 30176837
  4. ECH attenuated LPS-induced inflammation and apoptosis in rat intestine epithelial cells via suppressing the mTOR/STAT3 pathway. PMID: 29803175
  5. decreased expression of Stat3 and p-Stat3 were detected in the placenta of the preeclampsia-like rat model PMID: 29353343
  6. Intrathecal administration of the STAT3 inhibitor S3I-201 suppressed up-regulation of CX3CL1 at both the protein and mRNA levels after skin/muscle incision and retraction surgery PMID: 29313211
  7. Low STAT3 expression is associated with pulmonary ischemia/reperfusion injury. PMID: 29768493
  8. Sustained activation of STAT3 by hyperglycemia may promote the expression of fibrosisassociated signals, including CTGF and MMP9, in H9c2 cells. PMID: 29115516
  9. the upregulation of CXCL12 via TNF-alpha/IL-1beta-dependent STAT3 activation contributes to oxaliplatin-induced chronic pain. PMID: 29166835
  10. DUSP19 up-regulation inhibited IL-1beta-induced chondrocytes apoptosis and MMPs expression through inactivating JAK2/STAT3 pathway. PMID: 29174854
  11. The result on increased the present manifestation of STAT3 activation in remote dorsal root ganglia (DRG) following unilateral sciatic nerve injury may reflect a systemic reaction of the DRG neurons to nerve injury. PMID: 29488000
  12. TBI-induced autophagy was mediated by ERK1/2/mTOR/Stat3 pathway, which may serve to reduce ALI and improve pulmonary barrier function, oxygenation function and static compliance. These findings are important for the prevention and treatment of TBI-induced ALI. PMID: 29466698
  13. The studies findings implicate that JAK2/STAT3 pathway plays the vital role in cerebral ischemia/reperfusion injury protection from activating epidermal growth factor receptor. PMID: 29061394
  14. TGF-beta1-mediated hyaluronan/CD44/STAT3 signaling pathway plays a crucial role in the development of atrial fibrosis and atrial fibrillation. PMID: 28871329
  15. Data suggest that TLR4/STAT3 signaling pathway in VTA might play a critical role in the acquisition and maintenance of morphine CPP. PMID: 28827130
  16. PPARgamma agonist ROZ alleviated steatosis through reducing SOCS3 expression by inhibiting JAK2/STAT3 in hepatocytes. PMID: 29550470
  17. SERPINB1 decreased inflammation, ameliorated oxidative stress in the lung, and attenuated acute lung injury in rats with orthotopic autologous liver transplantation by activating HO-1 and it does so through STAT3 PMID: 28427999
  18. activation of oligodendroglial Stat3 is required for efficient remyelination PMID: 27060559
  19. these observations provide a novel mechanism of SGLT2 inhibitors-mediated M2 polarization through a RONS-dependent STAT3-mediated pathway and selective SGLT2 inhibitors are more effective in attenuating myofibroblast infiltration during postinfarction remodeling. PMID: 28132924
  20. JAK2 and STAT3 proteins in pancreatic exocrine cells were activated by high-dose linoleic acid via phosphorylation and nuclear localization of phosphorylated STAT3. PMID: 27450794
  21. Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling. PMID: 28187784
  22. role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation PMID: 27205876
  23. These findings suggest anti-inflammatory roles of CTGF-stimulated tendon stem cells that are likely associated with improved tendon healing. PMID: 28533328
  24. miR-21 overexpression promotes cardiac fibrosis via STAT3 signaling pathway by decrease CADM1 expression, indicating miR-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation. PMID: 28335740
  25. Together, these data indicate that novel nongenomic effects of STAT3 influence myocyte energy status and modulate AMPKalpha/mTOR signaling and autophagy to balance the transcriptional hypertrophic response to Ang II stimulation. PMID: 28686615
  26. Aldosterone -induced ERK1/2 activation is responsible for STAT3 activation. PMID: 28272757
  27. The JAK2-STAT3 pathway, a survival signaling pathway, is linked to apoptosis. PMID: 27337676
  28. Studied the fibrotic actions of STAT3 suppression in endothelial cells (ECs); investigated TGF-beta1/ALK5/Smad4 signaling pathway participation; found signaling pathway involvement dependent on TGF-beta1 secretion, the ALK5 activation pathway, and Smad4 translocation into the nucleus.Conclude that suppressed STAT3 expression converts ECs into activated fibroblasts via TGF-beta1/ALK5/Smad4 signaling pathway. PMID: 28737766
  29. STAT3 overexpression in corpus cavernosum smooth muscle in rats weakened the suppressive effect of PDGFR inhibition on the morphology and phenotypic transformation induced by PDGF-BB PMID: 28245285
  30. STAT3 inhibition with S3I-201 significantly reduced obstruction-induced MMP-9 expression and tubulointerstitial fibrosis PMID: 27760767
  31. Astrocyte expression of GLAST/GFAP was reduced via JAK1/JAK2/STAT3 signaling pathway after exposure to sevoflurane. PMID: 27003918
  32. myocyte-derived exosomes and myocyte-secreted IL-6 are responsible in unison for the biphasic activation of STAT-3 signaling in cardiac fibroblasts that culminates in excess collagen synthesis, leading to severely compromised cardiac function during cardiac hypertrophy. PMID: 28031326
  33. Data suggest taht the effect of Irisin on vascular smooth muscle cells (VSMCs) phenotype modulation might be signal transducer and activator of transcription 3 (STAT3)-dependent. PMID: 27416763
  34. A mutation in STAT3, a heterozygous C to T transition in exon 10 of the STAT3 gene at position 988 of the coding DNA sequence, leads to increased STAT3 activity and decreased insulin synthesis via inhibition of Isl-1. PMID: 28073828
  35. increased STAT3 levels after willed-movement training might play critical roles in the neural plasticity by directly regulating plasticity-related genes. PMID: 27381726
  36. PKCzeta interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy PMID: 27094369
  37. Catalpol affects neuroprotection and angiogenesis via the JAK2/STAT3 signaling pathway, up-regulating VEGF expression. PMID: 27301615
  38. The results suggest that neonatal MS experience may blunt the anorectic efficacy of leptin later in life, possibly in relation with increased expressions of PTP1B and/or pSTAT3 in the hypothalamus PMID: 28229972
  39. 2-arachidonylglycerol protects primary astrocytes exposed to oxygen-glucose deprivation through a blockade of NDRG2 signaling and STAT3 phosphorylation. PMID: 26414218
  40. These results demonstrate that Notch signaling protects against burn-induced myocardial injury through JAK2/STAT3 signaling, which activates the expression of MnSOD and leads to decreased reactive oxygen species levels. PMID: 27057278
  41. This study revealed an anti-proliferative property of plumericin towards vascular smooth muscle cells which depends on plumericin's thiol reactivity and S-glutathionylation of Stat3. PMID: 26858089
  42. These benefits appear to be attributed to the enhanced interaction between STAT3 and MnSOD. These findings shed a light on a new role of STAT3 in oxidative stress and suggest that ZYZ451 is likely an effective cardio-protective agent. PMID: 26721595
  43. Hepatoprotective effect of magnesium isoglycyrrhizinate is mediated by inhibiting the inflammatory response through inhibition of the STAT3 pathway. PMID: 26604644
  44. NogoA may regulate 1-methyl-4-phenylpyridiniuminduced neurotoxicity in PC12 cells via the mTOR/STAT3 signaling pathway. PMID: 26648565
  45. These findings indicated that honokiol protects against renal ischemia/reperfusion injury via the suppression of oxidative stress, iNOS, inflammation and STAT3 in the rat. PMID: 26647858
  46. Ang III, similar to Ang II, has pro-inflammatory effects since it induces STAT3 leading to an induction of IL-6 mRNA expression. PMID: 24961501
  47. IL-1beta and IFNgamma upregulate the expression of TRAF2 in insulin-producing INS-1E cells and isolated rat pancreatic islets. PMID: 26610752
  48. the adenylyl cyclase/cAMP/PKA pathway upregulates IL-1beta-induced IL-6 synthesis through enhancement of the JAK2/STAT3 pathway in C6 glioma cells PMID: 26527061
  49. HSP72 blocks fibroblast activation and proliferation in renal fibrosis via targeting the STAT3 pathway and may serve as a novel therapeutic agent for chronic kidney disease regardless of the etiology PMID: 26851345
  50. Prdx5 protects TGF-beta induced fibrosis. Prdx5 negatively modulates TGF-beta induced Stat3 activation. PMID: 26872211

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Subcellular Location Cytoplasm. Nucleus.
Protein Families Transcription factor STAT family
Tissue Specificity Detected in lung, heart, oviduct, ovary, uterus and kidney (at protein level). Detected in ovary, oviduct, and at lower levels in uterus and lung.
Database Links

KEGG: rno:25125

STRING: 10116.ENSRNOP00000026760

UniGene: Rn.10247

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