TGFB2

The gene TGFB2 encodes the protein Transforming Growth Factor Beta-2 (TGFβ-2), also known as BSC-1 cell growth inhibitor cetermin G-TSF glioblastoma-derived T-cell suppressor factor polyergin, and transforming growth factor beta-2. TGFβ-2 is a multifunctional cytokine that plays a crucial role in cell growth, differentiation, migration, and apoptosis. It binds to receptor proteins on cell surfaces, triggering signaling pathways that regulate various cellular activities. TGFβ-2 is involved in the TGF-β pathway, which controls cell proliferation, differentiation, motility, and apoptosis. Dysregulation of TGFβ-2 signaling is associated with several diseases, including Loeys-Dietz syndrome, Marfan syndrome, and aortic aneurysms. Research into TGFβ-2 and its signaling pathways has led to potential therapeutic targets for these conditions, with ongoing drug development efforts focusing on modulating TGFβ-2 activity.