TMPRSS2 (Transmembrane Serine Protease 2) is a transmembrane serine protease primarily found in epithelial cells, notably expressed at higher levels in tissues such as the lungs, intestines, and prostate. Its crucial function involves cleaving and activating other proteins, particularly viral proteins or other protein precursors. During viral infections like in SARS-CoV-2 (the virus causing COVID-19), the TMPRSS2 protein facilitates viral entry into host cells. In COVID-19 research, TMPRSS2 is considered to play a role in the process of SARS-CoV-2 virus entry into epithelial cells. Therefore, investigations targeting TMPRSS2 might contribute to the development of therapies targeting viral invasion
Recombinant Human Transmembrane protease serine 2 (TMPRSS2), partial (Active)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Recombinant Human TMPRSS2 His tag protein (CSB-YP023924HU) enzyme activity is measured by its ability to cleave fluorogenic peptide substrate(Boc-Gln-Ala-Arg-AMC), The Km is 21.93μM.
Activity
Measured by Camostat Mesylate inhibit ratio on TMPRSS2 (CSB-YP023924HU), which can cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC). The Camostat Mesylate inhibit EC50 is 0.03347-0.07945μM.
The following TMPRSS2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TMPRSS2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA971239 | TMPRSS2 Antibody |
Human | ELISA, WB |
CSB-PA023924ZA01HU | TMPRSS2 Antibody |
Homo sapiens | ELISA, WB (ensure identification of antigen) |
TMPRSS2 Proteins for Homo sapiens (Human)
TMPRSS2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-BP884918MO CSB-MP884918MO CSB-EP884918MO-B |
Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP884918MO | Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial |
E.coli |
CSB-YP884918MO | Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial |
Yeast |
CSB-YP884918MOc7 | Recombinant Mouse Transmembrane protease serine 2 (Tmprss2), partial |
Yeast |