Recombinant Human Interleukin-13 (IL13) (Active)

IL-13 drives Th2-polarized immune responses and plays a central role in allergic inflammation, fibrosis, and alternative macrophage activation, making precise functional studies of this cytokine essential for immunology research. This recombinant human IL-13 (residues 35–146) carries a C-terminal 6xHis tag and demonstrates robust signaling potency with an ED50 of 1.5–4.5 ng/mL in TF-1 cell proliferation assays, confirming its suitability for cell-based functional studies including JAK/STAT6 pathway activation, B-cell differentiation, and macrophage polarization experiments. Endotoxin levels below 1.0 EU/μg minimize LPS-driven artifacts that can confound immune cell readouts, supporting use in sensitive in vivo inflammation models and as a reference standard in cytokine detection assays. Mammalian-expressed to preserve native folding and post-translational modifications, this protein provides greater than 95% purity and aligns with standards expected in antibody development workflows such as ELISA coating or positive control applications.