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| Code | CSB-PA000123 |
| Size | US$167 |
| Uniprot No. | P04637 |
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| Immunogen | Synthesized peptide derived from the Human p53 around the acetylation site of K370. |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | WB,ELISA;WB:1/500-1/2000.ELISA:1/20000 |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Alias | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | Western Blotting(WB) Protocol ELISA Protocol |
| Target Names | TP53 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 |
| Involvement in disease | Esophageal cancer (ESCR); Li-Fraumeni syndrome (LFS); Squamous cell carcinoma of the head and neck (HNSCC); Lung cancer (LNCR); Papilloma of choroid plexus (CPP); Adrenocortical carcinoma (ADCC); Basal cell carcinoma 7 (BCC7) |
| Subcellular Location | Cytoplasm, Nucleus, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Note=Interaction with BANP promotes nuclear localization, Recruited into PML bodies together with CHEK2, Translocates to mitochondria upon oxidative stress, Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408), SUBCELLULAR LOCATION: Isoform 1: Nucleus, Cytoplasm, Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4, SUBCELLULAR LOCATION: Isoform 2: Nucleus, Cytoplasm, Note=Localized mainly in the nucleus with minor staining in the cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Nucleus, Cytoplasm, Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells, SUBCELLULAR LOCATION: Isoform 4: Nucleus, Cytoplasm, Note=Predominantly nuclear but translocates to the cytoplasm following cell stress, SUBCELLULAR LOCATION: Isoform 7: Nucleus, Cytoplasm, Note=Localized mainly in the nucleus with minor staining in the cytoplasm, SUBCELLULAR LOCATION: Isoform 8: Nucleus, Cytoplasm |
| Protein Families | P53 family |
| Tissue Specificity | Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 |
| Database Links |
HGNC: 11998 OMIM: 133239 KEGG: hsa:7157 STRING: 9606.ENSP00000269305 UniGene: Hs.437460 |
| Pathway |
MAPK signaling pathway
p53 signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Apoptosis Cell cycle Cellular senescence Cell ageing and metabolism Sphingolipid signaling pathway Neurotrophin signaling pathway |
TP53 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA024077GA01HU | TP53 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA07889B0Rb | TP53 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07889C0Rb | TP53 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA07889D0Rb | TP53 Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA0240771A0m | TP53 Monoclonal Antibody | Human | ELISA,WB,IHC |
| CSB-RA024077A55phHU | Phospho-TP53 (T55) Antibody | Human | ELISA, WB, IF |
| CSB-RA024077A33phHU | Phospho-TP53 (S33) Antibody | Human | ELISA, IHC, IF |
| CSB-PA572207 | Phospho-TP53 (Ser6) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA157242 | Phospho-TP53 (Ser15) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA109326 | Phospho-TP53 (Thr18) Antibody | Human | ELISA,WB |
| CSB-PA029276 | Phospho-TP53 (Ser33) Antibody | Human | ELISA,WB,IF |
| CSB-PA445853 | Phospho-TP53 (Ser37) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA945066 | Phospho-TP53 (Ser46) Antibody | Human | ELISA,WB,IF |
| CSB-PA826876 | Phospho-TP53 (Ser315) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA277007 | TP53 (Ab-6) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA599282 | TP53 (Ab-9) Antibody | Human | ELISA,WB |
| CSB-PA063047 | TP53 (Ab-15) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA992550 | TP53 (Ab-18) Antibody | Human | ELISA,WB |
| CSB-PA593512 | TP53 (Ab-33) Antibody | Human | ELISA,WB |
| CSB-PA923986 | TP53 (Ab-37) Antibody | Human | ELISA,WB |
| CSB-PA445446 | TP53 (Ab-46) Antibody | Human | ELISA,WB |
| CSB-PA964395 | TP53 (Ab-315) Antibody | Human | ELISA,WB |
| CSB-PA226168 | Phospho-TP53 (Ser20) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA449705 | Phospho-TP53 (Ser366) Antibody | Human,Rat | ELISA,WB |
| CSB-PA052612 | Phospho-TP53 (Ser392) Antibody | Human | ELISA,WB |
| CSB-PA870744 | TP53 (Ab-378) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA000096 | Di-Methyl-TP53 (K370) Antibody | Human | WB,ELISA |
| CSB-PA000124 | Acetyl-TP53 (K372) Antibody | Human | WB,ELISA |
| CSB-PA000135 | Acetyl-TP53 (K373) Antibody | Human | WB,ELISA |
| CSB-PA000136 | Acetyl-TP53 (K382) Antibody | Human | WB,ELISA |
| CSB-PA000140 | Acetyl-TP53 (K320) Antibody | Human | WB,ELISA |
| CSB-PA000595 | Phospho-TP53 (S15) Antibody | Human,Rat | WB,IHC,IP,IF,ELISA |
| CSB-PA000596 | Phospho-TP53 (S20) Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ELISA |
| CSB-PA000597 | Phospho-TP53 (S315) Antibody | Human | WB,IHC,IP,ELISA |
| CSB-PA000598 | Phospho-TP53 (S33) Antibody | Human | WB,ELISA |
| CSB-PA000599 | Phospho-TP53 (S46) Antibody | Human,Monkey | WB,ELISA |
| CSB-PA000600 | Phospho-TP53 (S6) Antibody | Human,Monkey | WB,IHC,IP,ELISA |
| CSB-PA000602 | Phospho-TP53 (S9) Antibody | Human,Monkey | WB,IHC,ELISA |
| CSB-PA000603 | Phospho-TP53 (T18) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA000632 | Phospho-TP53 (S37) Antibody | Human | WB,IHC,ELISA |
| CSB-PA003666 | TP53 Antibody | Human,Monkey | WB,ELISA |
| CSB-PA003667 | TP53 Antibody | Human,Mouse,Rat,Monkey | WB,ELISA |
| CSB-PA003668 | TP53 Antibody | Human,Monkey | WB,IHC,IF,ELISA |
| CSB-PA003670 | TP53 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA003672 | TP53 Antibody | Human,Monkey | WB,IHC,IF,ELISA |
| CSB-PA003675 | TP53 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA003676 | TP53 Antibody | Human | WB,ELISA |
| CSB-PA003677 | TP53 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA003678 | TP53 Antibody | Human,Rat,Monkey | WB,IHC,IF,ELISA |
| CSB-PA003680 | TP53 Antibody | Human | WB,IHC,IF,ELISA |
| CSB-PA005967 | TP53 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA050293 | Acetyl-TP53 (K386) Antibody | Human | IHC,IF,ELISA |
| CSB-PA050295 | Phospho-TP53 (S378) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA050296 | Phospho-TP53 (S366) Antibody | Human | WB,IHC,ELISA |
| CSB-PA050297 | Phospho-TP53 (S392) Antibody | Human,Monkey | WB,IHC,IF,ELISA |
| CSB-PA050298 | Phospho-TP53 (T81) Antibody | Human | IHC,ELISA |
| CSB-PA050299 | Phospho-TP53 (T387) Antibody | Human | IHC,ELISA |
| CSB-PA050300 | Phospho-TP53 (S376) Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA050301 | TP53 Antibody | Human | WB,IHC,ELISA |
| CSB-PA050302 | TP53 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA050303 | TP53 Antibody | Human | WB,ELISA |
| CSB-PA050304 | TP53 Antibody | Human | IHC,ELISA |
| CSB-PA050305 | TP53 Antibody | Human,Mouse,Rat,Monkey | WB,IHC,IF,ELISA |
| CSB-PA050306 | TP53 Antibody | Human,Mouse,Rat,Monkey | WB,IHC,IF,ELISA |
| CSB-PA080174 | TP53 Antibody | Mouse,Rat | WB,IHC |
| CSB-MA080273 | Mono-Methyl-TP53(Lys370) Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA150453 | TP53 Antibody | Human | ELISA,WB |
| CSB-RA024077A09phHU | Phospho-TP53 (S9) Antibody | Human | ELISA, IF |
| CSB-RA024077A392phHU | Phospho-TP53 (S392) Antibody | Human | ELISA, WB |
| CSB-PA847762 | Phospho-TP53 (Ser366) Antibody | Human | WB,ELISA |
TP53 Antibodies for H
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-MA000208 | TP53 Monoclonal Antibody | Human | ELISA,WB,IHC,IF |
TP53 Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA050291 | Acetyl-TP53 (K317) Antibody | Human | ELISA |
| CSB-PA050292 | Acetyl-TP53 (K381) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-MA531279 | Acetyl-TP53(K382) Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA746672 | Acetyl-TP53(K382) Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA374487 | Acetyl-TP53(K382) Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
TP53 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA07889A0Rb | TP53 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, ChIP |
TP53 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP024077HU | Recombinant Human Cellular tumor antigen p53(TP53) | Yeast |
| CSB-EP024077HU | Recombinant Human Cellular tumor antigen p53(TP53) | E.coli |
| CSB-BP024077HU CSB-MP024077HU |
Recombinant Human Cellular tumor antigen p53(TP53) | Baculovirus Mammalian cell |
TP53 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08334h | Human p53/tumor protein,p53/TP53 ELISA Kit | serum, cell culture supernates, urine, cerebrospinal fluid (CSF), tissue homogenates, cell lysates | 2.34 pg/mL |
2-hydroxyisobutyryl-HIST1H2BC (K24) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K8) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
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