CREB1 Antibody

Datasheet
Code CSB-PA005947HA01HU
Size US$299
Image
  • Western Blot
    Positive WB detected in: Mouse brain tissue
    All lanes: CREB1 antibody at 3.3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 37, 36, 26 kDa
    Observed band size: 37 kDa

  • Immunohistochemistry of paraffin-embedded mouse brain tissue using CSB-PA005947HA01HU at dilution of 1:50

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CREB1 Polyclonal antibody
Uniprot No. P16220
Target Names CREB1
Alternative Names Active transcription factor CREB antibody; cAMP response element binding protein 1 antibody; cAMP response element binding protein antibody; cAMP responsive element binding protein 1 antibody; cAMP-responsive element-binding protein 1 antibody; CREB antibody; CREB-1 antibody; CREB1 antibody; CREB1_HUMAN antibody; Cyclic AMP-responsive element-binding protein 1 antibody; MGC9284 antibody; OTTHUMP00000163864 antibody; OTTHUMP00000163865 antibody; OTTHUMP00000206660 antibody; OTTHUMP00000206662 antibody; OTTHUMP00000206667 antibody; Transactivator protein antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Cyclic AMP-responsive element-binding protein 1 protein (1-341AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Gene References into Functions
  1. findings illustrate the significance of CREB-KDM4B-STAT3 signaling cascade in DNA damage response, and highlight that KDM4B may potentially be a novel oncotarget for colorectal cancer radiotherapy. PMID: 29633065
  2. CacyBP expression is regulated by E2F1, EGR1, and CREB transcription factors in colorectal cancer HCT116 cells. PMID: 29197151
  3. ethanol-induced eIF2alpha phosphorylation stimulates COX-2 expression and PGE2 production which induces the BACE1 expression and Abeta production via EP-2 receptor-dependent PKA/CREB pathway. PMID: 28668332
  4. Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli. PMID: 28383034
  5. CREB1 overexpression rescued the effects on gastric cancer cell growth induced by miR-1297. PMID: 29870889
  6. Results suggest that low nuclear cyclic AMP responsive element binding protein (pCREB) expression in the primary lesion is significant risk factor for metastatic melanoma. PMID: 29179997
  7. Via activation of cAMP/PKA/CREB pathway and upregulation of the downstream FtMt expression. PMID: 30069985
  8. The mechanism of prostaglandin E2-induced transcriptional up-regulation of Oncostatin-M by CREB and Sp1 has been described. PMID: 29269396
  9. The findings suggest that activation of TGR5 promoted mitochondrial biogenesis in endothelial cells, which is mediated by the CREB/PGC-1a signaling pathway. PMID: 29709472
  10. High CREB expression is associated with esophageal squamous cell carcinoma. PMID: 29286131
  11. CREB1 may activate the transcription of wtBRAF through directly binding to its promoter, increasing BRAF expression and regulating the cell proliferation, migration and invasion of endometriosis. PMID: 29286077
  12. to explore genetic variations in CREB1 promoter region and determine whether these loci affect transcriptional activity and risk on type 2 diabetes (T2D). Three polymorphisms were identified and designated as MU1, MU2 and MU3, respectively. Genotypic distribution analysis revealed that MU1 genotypes presented similar distribution between T2D and healthy controls (P>0.05) PMID: 29729382
  13. experiments mainly reveal that the CREB1 could affect glucose transport in glioma cells by regulating the expression of GLUT1, which controlled the metabolism of glioma and affected the progression of glioma. PMID: 28646353
  14. These data highlight a novel arrestin-mediated modulation of CREB signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR to activate prolonged CREB phosphorylation by precluding recruitment of an arrestin2/Src/p38 complex. PMID: 28733084
  15. The authors conclude that taurodeoxycholic acid-induced DNA damage may depend on the activation of TGR5, CREB and NOX5-S. It is possible that in Barrett's patients bile acids may activate NOX5-S and increase reactive oxygen species (ROS) production via activation of TGR5 and CREB. NOX5-S-derived ROS may cause DNA damage, thereby contributing to the progression from Barrett's esophagus to esophageal adenocarcinoma. PMID: 27511066
  16. The mechanism of CBP-CREB association via their pKID/KIX domains studied by molecular dynamics free energy simulations has been reported. PMID: 27054660
  17. Results indicate CREB1 as a critical transcription factor of RRM2 which promotes tumor aggressiveness, and imply a significant correlation between CREB1 and RRM2 in CRC specimens. PMID: 27801665
  18. Study suggest that both p300 and CREB are required for the function integrity of HIF-1alpha transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300, CREB and HIF-1alpha. PMID: 27808477
  19. These findings suggest that CREB1 may be a potential therapeutic target for the treatment of gastric cancer PMID: 28498439
  20. YAP/ TAZ pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 and CREB PMID: 27527859
  21. Data demonstrate that CREB is downregulated in glioma cells and is a direct target of miR-433-3p. These findings indicate that CREB subsequently directly or indirectly modulates its target genes to control the cell growth and metastasis in glioma. PMID: 27926502
  22. these studies demonstrate that transcription factors CREB and c-Myc maintain the transcriptional activity of STING PMID: 27835584
  23. GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells. PMID: 27191986
  24. miR-150 is a novel Wnt effector that may significantly enhance epithelial-mesenchymal transition of colorectal cancer cells by targeting the CREB signaling pathway PMID: 27285761
  25. fMRI and genotyping data from a large human sample, together with previous evidence, support the view that CREB1-associated mechanisms modulate brain function and behavior during reward-based decision-making. PMID: 26045569
  26. Knockdown of either HIF-1 or CREB or both in hypoxia reduced the expression of hypoxia-response elements- and CRE-mediated gene expression, diminished cell proliferation and increased caspase-3 activity. PMID: 27934882
  27. MnTE-2-PyP decreased p300 complex binding to a specific HRE motif within the PAI-1 gene promoter region, suppressed H3K9 acetylation, and consequently, repressed PAI-1 expression. Mechanistically, less p300 transcriptional complex binding is not due to the reduction of binding between p300 and HIF-1/CREB transcription factors, but through inhibiting the binding of HIF-1/CREB transcription factors to DNA PMID: 26944191
  28. Inhibition of CaN attenuated the hTau-induced CREB dephosphorylation with improved synapse and memory functions. PMID: 27298345
  29. Via blocking the hypoxia-mediated reduction in CREB phosphorylation. PMID: 28254846
  30. The study adds evidence that CREB, a tumor oncogene, promotes renal cell carcinoma proliferation. It probably achieves this by increasing SKA2 expression PMID: 26824422
  31. cigarette smoke extracts activate the PKA, CREB, and IL-13Ralpha2 axis in lung endothelial cells. PMID: 27986643
  32. This study showed that the induction level of IL-32 was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS-induced IL-32 expression in nasal polyp-derived fibroblasts was regulated via the TLR4/JNK/AKT/CREB signaling pathway. PMID: 27173130
  33. Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB) protein (CBP)/beta-catenin or gamma-catenin interaction. PMID: 28479420
  34. Study indicates that BPA increases phosphorylated CREB in MCF-7 Cells as well as it binding to SOX2 enhancer. PMID: 28244015
  35. study concludes that miR-132 regulated SIRT1/CREB/ABCG2 signaling pathway contributing to the cisplatin resistance and might serve as a novel therapeutic target against gastric cancer PMID: 28383763
  36. Leptin also significantly increased cAMP levels, cAMP response element (CRE) activation, and CREB phosphorylation. PMID: 28571770
  37. these data show the existence of functional CREB and C/EBP binding sites in the human RIC8B gene promoter, a particular distribution of these sites and demonstrate a relevant role of CREB in stimulating transcriptional activity of this gene. PMID: 26729411
  38. MALAT1 knockdown reduces reactive gliosis, Muller cell activation, and RGC survival in vivo and in vitro MALAT1-CREB binding maintains CREB phosphorylation by inhibiting PP2A-mediated dephosphorylation, which leads to continuous CREB signaling activation. PMID: 26964565
  39. aberrant activation of CREB-C/EBPdelta axis concurring to AML onset by disrupting the myeloid cell differentiation process PMID: 27118402
  40. miR-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 levels in breast cancer tissues. PMID: 27809310
  41. Interactions between GNB3, CREB1 and negative life events were revealed. Further evidence is provided about the role of the environment in genetic vulnerability to major depression. PMID: 28225778
  42. Our study establishes a robust human stem cell-based platform for consistent quantitative evaluation of genotype-dependent Rett syndrome (RTT) phenotypes at the cellular level. PMID: 28270572
  43. UCA1 promotes cisplatin/gemcitabine resistance in bladder cancer cells through CREB modulation of miR-196a-5p expression. PMID: 27591936
  44. Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1/CREM fusions. PMID: 28009602
  45. CREB1/FoxA1 signaling is a targetable driver of prostate cancer progression and serves as a biomarker of poor clinical outcomes. PMID: 26743006
  46. These results suggest that the HIPK2-phospho-Ser271 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-phospho-Ser133 CREB axis. PMID: 27884605
  47. There were decreased levels of Gsa, FOXF1, CREB1, and phosphorylated CREB1 proteins in intestinal muscle layers of patients with chronic intestinal pseudo-obstruction, compared with tissues from controls. PMID: 28043906
  48. Regulatory elements for both IRF-1 (-1019 to -1016) and CREB (-1198 to -1195), specific to the distal THBS1 promoter, were required for leptin-induced TSP-1 transcription. PMID: 27281481
  49. The results suggest that Sirt2 plays a crucial role in neuronal differentiation via the ERK-CREB signaling pathway. PMID: 27838300
  50. revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 in T cells, such as Raptor, CHEK1, CREB1, RUNX1, SATB1, Ikaros, and Helios. PMID: 27637333
  51. Here, the authors report that varicella-zoster virus infection also induced CREB phosphorylation in fibroblasts and that XX-650-23, a newly identified inhibitor of the phosphorylated-CREB (pCREB) interaction with p300/CBP, restricted cell-cell spread of varicella-zoster virus in vitro. PMID: 27440893
  52. all of these features of CREB in HL strongly support its role as a tumor suppressor gene that can decelerate cell proliferation by inhibiting the expression of several cell cycle-related genes. PMID: 27458098
  53. observations indicate that induced expression of miR-15b is modulated by c-Rel and CREB in response to JEV infection PMID: 26931521
  54. A critical role was determined for CREB in cell proliferation, cell survival and apoptosis in B-cell precursor acute lymphoblastic leukemia cells. PMID: 28063408
  55. SMND-309 can prevent neuronal cell death in vitro via activation of the PI3K/Akt/CREB-signalling pathway. PMID: 26911316
  56. This implies the key role played by CREB signaling in hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes PMID: 27323157
  57. upregulation of CREB expression that allows sufficient level of activated and phosphorylated protein is the primordial event that promotes the induction of genes of the DNA Damage Response. Then and when the DNA repair is effective, CREB induces detoxification and survival genes. This kinetics seems to be important to completely resolve oxidative-induced neuronal damages. PMID: 27816995
  58. We found that the concomitant diazepam equivalent dose and the presence of the CREB1 rs4675690 polymorphism were associated with antidepressant maintenance doses in Japanese patients with depression PMID: 27320498
  59. CREB signaled independent of cAMP signaling and was phosphorylated by p38 MAPK following TNF-alpha stimulation, playing a critical role in GM-CSF secretion in human lung fibroblasts. PMID: 27118435
  60. CREB is a transcriptional regulator of C/EBPbeta in gastric cancer cells.IL-1B signaling regulates expression and activation status of CREB in gastric cancer cells. PMID: 25740226
  61. CREB overexpression is associated with Acute Myeloid Leukemia. PMID: 26840025
  62. Results propose that CREB1 is an oncogene in renal cell carcinoma (RCC) and that upregulation of CREB1 by loss of tumor suppressive miR10b5p and miR3633p plays an important role in the tumorigenesis of RCC. PMID: 26796749
  63. This study reveals that miR-433-c-MET/CREB1-Akt/GSK-3beta/Snail signaling is critical to EMT in bladder cancer. PMID: 26844702
  64. rs7591784 near CREB1 is significantly associated with methamphetamine abuse before and use during treatment. PMID: 26736037
  65. Anxiety disorder comorbidity was the stronger predictor of current suicide risk and significant associations were found with variations in rs13515 (MAPK1) and rs6740584 (CREB1) polymorphisms. PMID: 26626456
  66. C/EBPalpha inhibited breast cancer cell growth via a novel miR-134/CREB signaling pathway. PMID: 26823765
  67. miR-124 suppresses seizure activity and regulates CREB1 activity. (Review) PMID: 26996991
  68. miR-506 significantly decreased the expression and transcription activity CREB1 to inhibit esophageal squamous carcinoma cell proliferation. PMID: 26617801
  69. CREB1 is phosphorylated following activation of ESR1 by estradiol. PMID: 26348925
  70. the early induction and activation of NF-kappaB1 in Ramos cells could mediate necrotic cell death and be linked to other molecules belonging to CREB family and involved in the cell cycle regulation. PMID: 26573110
  71. PFOS may inhibit BDNF-ERK-CREB signalling by increasing miR-22 levels, which may, in part, explain the mechanism of PFOS neurotoxicity PMID: 26649298
  72. CREB plays an important role in the inhibition of IGF2R expression by binding to the IGF2R promoter and further suppresses H9c2 cardiomyoblast cell apoptosis induced by IGF2R signaling under hypoxic conditions. PMID: 26610485
  73. serum starvation induces CREB1 expression, in turn activating miR-320a expression, which then down-regulates VDAC1 expression to facilitate mitophagy PMID: 26472185
  74. demonstrated that GSK-3alpha is regulated by CREB in lung cancer and is required for the cell viability. These findings implicate CREB-GSK-3alpha axis as a novel therapeutic target for lung cancer treatment PMID: 27049759
  75. CREB is a negative regulator of the TNFAIP1 gene. PMID: 26398148
  76. Both OGG1 and UNG2 impede CREB1 from binding to a binding site consensus sequence (CRE)substrate when the CRE site contains the specific DNA lesion recognized by each glycosylase. PMID: 26757817
  77. High expression of ROR1 (63%), pAkt (36%), and pCREB (20%) was observed in gastric adenocarcinomas, and expression of these proteins was well intercorrelated. PMID: 26245996
  78. MyD88s is positively regulated by IKKbeta and CREB and negatively regulated by ERK1/2 signaling pathways. PMID: 26669856
  79. Our data demonstrated that a specific decrease of GABARAPL1 expression in breast cancers was associated with both DNA methylation and histone deacetylation and that CREB-1 recruitment on GABARAPL1 PMID: 26474850
  80. TRAF3 regulates B-cell survival via inhibition of CREB stability PMID: 26755589
  81. CREB plays a key role in the K-RAS(V12)-mediated neoplastic phenotype and represents a suitable therapeutic target for murine and human K-RAS(V12)-induced tumors PMID: 25934695
  82. EMSA and ChIP assay confirmed the direct binding of activated CREB to the CREB binding site of 5' SPHK2 promoter region PMID: 25808826
  83. GABPalpha Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1 PMID: 26185160
  84. Taken together, we conclude that CREB protects tumor cells from gamma-irradiation, and combination of CREB inhibition plus ionizing radiation will be a promising radiotherapeutic approach. PMID: 26655813
  85. LF triggered CREB1 phosphorylation in IL-1beta-induced Human articular chondrocytes apoptosis through AKT1 signaling. PMID: 26279447
  86. Active CREB1 promotes a malignant TGFbeta2 autocrine loop in glioblastoma. PMID: 25084773
  87. Novel Epigenetic CREB-miR-630 Signaling Axis Regulates Radiosensitivity in Colorectal Cancer PMID: 26263387
  88. This study demonstrates a new role for CREB as a regulator of ER stress, which is required to properly respond to stressful conditions, such as hypoxia. PMID: 26642955
  89. CREB is involved in the regulation of MM pathogenesis by regulation of inflammation. PMID: 25111229
  90. Data indicate an important role for cyclic-AMP responsive element binding protein 1 (CREB) transcription factor in the survival of acute lymphoblastic leukemia (ALL) cells and as a potential target for treatment. PMID: 26008971
  91. These results demonstrated that the inhibitory effects of resveratrol on MDR1 expression in HCT116/L-OHP cells were closely associated with the inhibition of NF-kappaB signaling and CREB activation in an AMPK-dependent manner. PMID: 26124005
  92. The binding of CREB to the promoter region, -216 to +115, enhanced IA-2 transcription by more than fivefold. PMID: 25528004
  93. Results suggest that genetic variations in CREB-BDNF and other pathways partially explain the variance of precuneus reactivity to alcohol cues which appears to be associated with alcohol use disorder severity PMID: 25939814
  94. Hepatitis B virus core protein activates Enhancer I through its binding to cAMP response element (CRE), increasing the concurrent accumulation of CREB/CBP on CRE, and thus increases CRE transcriptional activation. PMID: 25936964
  95. CREB enhances KLF4 up-regulatory effect on apoE promoter. PMID: 26546821
  96. CREB1 was highly expressed and correlated with lymph node metastasis, distant metastasis and tumor stage and poor outcome in gastric cancer. PMID: 25825983
  97. Its transcription is down regulated by amyloid beta protein. PMID: 26025137
  98. Neither single-marker nor haplotypic association were found between suicide risk and/or a personal history of suicide attempt with any of the investigated SNPs after multiple testing correction PMID: 24955721
  99. CREB activation is essential for EGF-induced SGLT1 gene expression. PMID: 25936754
  100. Our results demonstrate that CREB is proto-oncogene, and the phosphorylated level of CREB at Ser 133 site influences the growth and metastatic activity of renal cancer PMID: 26036429

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Involvement in disease Angiomatoid fibrous histiocytoma (AFH)
Subcellular Location Nucleus
Protein Families BZIP family
Database Links

HGNC: 2345

OMIM: 123810

KEGG: hsa:1385

STRING: 9606.ENSP00000387699

UniGene: Hs.516646

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