Recombinant Mouse T-lymphocyte activation antigen CD86 (Cd86), partial

1. Our results reveal a role for B7-2 as obligatory receptor for superantigens. B7-2 homodimer interface mimotopes prevent superantigen lethality by blocking the superantigen-host costimulatory receptor interaction. PMID: 27708164
2. results suggest that the TLR2-p38-CD86 signaling pathway plays a vital role in inflammation associated with burn injury PMID: 28460187
3. role with CD40 in primary germinal center generation of distinct antigen-presenting cells PMID: 28768709
4. B7.2 expressed on skin CD8(+) T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs. PMID: 27183612
5. Low CD86 expression is associated with B16 melanoma. PMID: 26485753
6. Local administration of CD86 siRNA during the effector phase ameliorates asthma phenotypes. PMID: 25344652
7. Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD86. PMID: 24981893
8. novel function of CTLA4Ig in tumor immunity and suggest that CD86 on NK cells is an activating receptor and closely involved in the CTLA4Ig-mediated anti-tumor response. PMID: 24349559
9. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice. PMID: 24708417
10. CD86 expression has functional consequences for the magnitude of CD4 T cell responses both in vitro and in vivo. These data pinpoint CD86 upregulation as an additional mechanism by which IL-21 can elicit immunomodulatory effects. PMID: 24470500
11. the results presented here demonstrate that recruitment and expression of MHC-II, CD80, CD86, PDL1, and PD-L2 in M of peritoneal cavity in T. crassiceps early at infection is associated to the sex of the host. PMID: 23533995
12. Combinatorial signaling through TLR-2 and CD86 augments B-cell receptor-free activation and differentiation of resting B cells. PMID: 23365665
13. Phb1/2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IgG1. PMID: 23241883
14. In response to Pseudomonas infection, mobilized neutrophils upregulate and provide B7 trans-costimulatory signals to T cells, preventing established lung allograft tolerance. PMID: 23018463
15. Data indicate that most toll-like receptor (TLR) ligands induced comparable upregulation of co-stimulatory molecules CD40, CD86 and B7H1 on young and aged conventional dendritic cells (cDC). PMID: 22231652
16. Interaction between CD28 and B7 molecules is required for regulation of splenic and bone marrow plasma cells. PMID: 22908331
17. B7 and CD28 interactions promote the proliferation and survival of murine gammadelta T cells following Plasmodium infection. PMID: 22732586
18. Yeast-derived beta-glucan lacks cytotoxic effects towards B-lymphoma cells but up-regulation of CD86 suggests maturation of the cells via dectin-1 by the carbohydrate PMID: 22199280
19. Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1). PMID: 21896490
20. Parasite-induced B7-2 is dependent on Jun N-terminal protein kinase (JNK) but not extracellular signal-regulated kinase or p38 signaling; its expression on human peripheral blood monocytes is dependent on JNK signaling. PMID: 21911468
21. These studies suggest that ubiquitination serves as an important mechanism by which dendritic cells control CD86 expression PMID: 21849678
22. T-cell costimulation via B7 ligands (CD80 and CD86) is essential for development of experimental hypertension; inhibition of this process could have therapeutic benefit in the treatment of this disease. PMID: 21126972
23. CD86 is critical for naive CD4+ T cell activation in vivo and differentiation into either a Th1 or Th2 phenotype. PMID: 11937530
24. B7-2 in deleting pathogenic autoreactive T cells in the thymus. PMID: 11956287
25. B cell-associated B7-2 expression is regulated by stimulation of the B cell receptor and/or the beta 2-adrenergic receptor in vivo and in vitro. PMID: 12055247
26. Activation-induced up-regulation of B7-2 on antigen presenting cells leads to increased CD28 signaling and a commitment to cross-priming of CD4-dependent cytotoxic T lymphocytes. PMID: 12370335
27. Role of CD86 in enhancing cell-cycle progression and survival of CD4(+) T lymphocytes after activation. PMID: 12429713
28. fate of LACK-specific CD4+ T cells in Leishmania-infected BALB/c mice which have been treated or not with anti-CD86 mAb PMID: 12516542
29. Although CD86 plays a critical role in T-dependent IgG and IgE responses of B cells to in vivo antigenic challenge, direct CD86 signaling of a B cell is not essential for its efficient activation. PMID: 12517941
30. Stimulation by CD86, either alone or together with beta 2-AR on a CD40ligand/IL-4 activated B cell, increases both the level and the rate of mature IgG1 transcription without affecting transcript stability or class switching to IgG1. PMID: 12734361
31. B7-2 and B7-1 have overlapping functions in the endogenous superantigen-mediated deletion of TCR V beta 11- or V beta 12-bearing thymocytes. PMID: 12759417
32. B7-2 overexpressed on transgenic donor T cells mediates reduced alloresponsiveness and mortality in graft-vs-host disease compared with wild-type T cells. PMID: 14688306
33. stimulation of matured bone marrow dendritic cells with anti-CD80 monoclonal antibody up-regulated CD86 levels on the cell surface Coculture of these cells with naive, allogeneic T cells downregulated Th1 responses and upregulated suppressor responses PMID: 14966193
34. T cells activated in the presence of parenchymal cells from the eye express B7-2 in a manner that equips them to suppress bystander T cells. Thus, B7-2 expression on T cells participates in their eventual ability to function as regulators in vitro. PMID: 15034031
35. increased surface expression on Mycobacterium tuberculosis secretory antigen (MTSA)activated dendritic cells after stimulation with M. tuberculosis cell extract downregulates the Th1 cells response to Mycobacterial antigens PMID: 15116295
36. B7-2 plays a critical role in priming pancreatic islet-reactive CD4 T cells: B7-2 deficiency causes a profound diminishment in the generation of spontaneously activated CD4 T cells and islet-specific CD4 T cell expansion. PMID: 15356107
37. Increased B7-2 expression on islet-infiltrated nonobese diabetic (NOD) mouse B cells is associated with increased T cell costimulation and the development of inflammatory insulitis in NOD mice. PMID: 15634886
38. CD86 plays a critical role in induction of anterior chamber-associated immune deviation. PMID: 15778288
39. Could not be expressed on keratinocyte stem cells. PMID: 15808622
40. upregulated in SV5 infection of dendritic cells in both BALB/c and C57BL/6 mice strains PMID: 15919909
41. Tolerance may be induced by B7-driven negative regulatory signaling, but tolerance is maintained by a lack of signal 2 (B7.2), because expression of B7 is eventually lost in vivo. PMID: 16002674
42. CD86 is protective in glomerulonephritis by enhancing Th2 and attenuating Th1 responses PMID: 16014035
43. CD86 is not required for oral tolerization. PMID: 16439314
44. CD86 induces a previously unknown signal transduction pathway that regulates the level of B cell gene expression and activity proximal to NF-kappa B activation. PMID: 16709832
45. B7-1 and B7-2 differently contribute to the development of T cell-mediated experimental allergic conjunctivitis during the induction and effector phases PMID: 17109973
46. Data indicate that anti-B7-2 monoclonal antibody B7 molecules can trigger innate-effector responses in macrophages by activating NF-kappaB, and are not only essential for induction of adaptive immune responses but also play roles in innate immunity. PMID: 17314080
47. B7-2 promotes the generation of a mature antigen-presenting cell (APC) repertoire and promotes APC function and survival. PMID: 17475851
48. Either CD80- or CD86-costimulation is indispensable for induction of oral sensitization and IgE-mediated hypersensitivity to peanut, with CD86 being the most important ligand in inducing peanut extract-specific IgE responses. PMID: 17513738
49. CD86 plays a key role in regulating the level of B-cell IgG1 produced in vitro and in vivo. PMID: 17641017
50. while CD86 does not stimulate an initial response as strongly as CD80, there is greater sustained activity that is seen even in the absence of continued costimulation PMID: 17947667

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KEGG: mmu:12524

STRING: 10090.ENSMUSP00000087047

UniGene: Mm.1452