Recombinant Rat Monocyte differentiation antigen CD14(Cd14)

Code CSB-YP737216RA
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Source Yeast
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Code CSB-EP737216RA
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Source E.coli
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Code CSB-EP737216RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP737216RA
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Source Baculovirus
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Code CSB-MP737216RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Cd14
Uniprot No. Q63691
Alternative Names Cd14Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD antigen CD14
Species Rattus norvegicus (Rat)
Expression Region 18-342
Target Protein Sequence SPA TPEPCELDQD EESVRCYCNF SDPQPNWSSA FLCAGAEDVE FYGGGRSLEY LLKRVDTEAN LGQYTDIIRS LPLKRLTVRS ARVPTQILFG TLRVLGYSGL RELTLENLEV TGTALSPLLD ATGPDLNTLS LRNVSWATTD TWLAELQQWL KPGLKVLSIA QAHSLNFSCK QVGVFPALAT LDLSDNPELG EKGLISALCP HKFPTLQVLA LRNAGMETTS GVCSALAAAR VPLQALDLSH NSLRDTAGTP SCDWPSQLNS LNLSFTGLEH VPKGLPAKLS VLDLSYNRLD RKPRPEELPE VGSLSLTGNP FLHSESQSEA YN
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2
Gene References into Functions
  1. This study shows that sCD14 impairs contractile function and insulin action in primary adult rat cardiomyocytes. PMID: 27816522
  2. CD 14 mRNA expression increased significantly after five days of bile duct ligation in liver, lung, spleen, and ileum. PMID: 25093541
  3. biliary drainage affects expression of inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats PMID: 23613625
  4. Burn injury-induced mitochondrial damage in cardiomyocytes was prevented in CD14 knockout mice. Burn injury produces CD14-dependent mitochondrial damage via oxidative stress in myocardium. PMID: 20348223
  5. Acute cerebral hemorrhage results in endotoxemia and widespread increases in CD14 and IL-1beta expression. PMID: 19534684
  6. Expression of CD14 protein and its gene in liver sinusoidal endothelial cells during endotoxemia. PMID: 12046090
  7. Increase of CD14 mRNA expression may result in greater sensitivity to endotoxin and thus lead to liver injury. PMID: 12113681
  8. Although microglial-derived CD14 does not contribute to early events triggered by intrastriatal endotoxin treatment, it modulates the duration of inflammation within the cerebral tissue. PMID: 12218159
  9. Ethanol administration led to a significant synthesis of endotoxin receptor CD14 protein and its gene expression in Kupffer cells, which maybe result in the pathological changes of liver tissue and hepatic functional damages. PMID: 12632533
  10. the CD14 antigen system appeared to be an early trigger for Kupffer cell activation followed by induction of inflammatory cytokine interleukin-1beta synthesis leading to hepatic injury after partial hepatectomy PMID: 14572767
  11. CD14 glycoprotein is present on the cell membranes of vascular smooth muscle cells of rat aorta, where it acts as a lipopolysaccharide receptor. PMID: 15153652

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Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor, Secreted, Membrane raft, Golgi apparatus
Tissue Specificity Detected in macrophages and peripheral blood monocytes.
Database Links

KEGG: rno:60350

STRING: 10116.ENSRNOP00000023977

UniGene: Rn.42942

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