ATF4, activating transcription factor 4, alias CREB-2.ATF4 is a basic region leucine zipper transcription factor, a member of the bZIP family, encoded by the ATF4 gene in the human genome. It plays a key role in cellular regulation of multiple stress responses, including amino acid deficiency, oxidative stress, and endoplasmic reticulum stress, etc. The mechanism of action of ATF4 is mainly to regulate the transcription of downstream genes by binding to cAMP response elements (CREs) on the promoter regions of target genes or to the associated DNA sequences.
The biological significance of ATF4 is mainly reflected in its regulation of cellular metabolism, survival and stress response regulation. It is involved in the regulation of amino acid metabolism, antioxidant response, protein folding and damage repair. During endoplasmic reticulum stress, ATF4 can activate the unfolded protein response (UPR) to help cells restore protein homeostasis. In addition, ATF4 is involved in the regulation of the cell cycle, apoptosis, and autophagy, affecting cell fate.Abnormal function of ATF4 has been associated with a variety of diseases, including metabolic disorders, neurodegenerative disorders, and certain types of cancers, making it a potential target in drug development.
Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) (CSB-EP880648RA)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ATF4 Antibody (CSB-PA002272KA01HU)
Validated Data
Western blot analysis of extracts from mouse craniofacial and mouse gastrocnemius, using ATF4 antibody.
Immunohistochemistry of paraffin-embedded Breast cancer using ATF4 Antibody.
The following ATF4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ATF4 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002272GA01HU | ATF4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA002272KA01HU | ATF4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA599947 | Phospho-ATF4 (Ser245) Antibody | Human | ELISA,WB,IHC |
CSB-PA172388 | Phospho-ATF4 (Ser219) Antibody | Human,Mouse | ELISA,WB |
CSB-PA123639 | ATF4 (Ab-219) Antibody | Human,Mouse | ELISA,WB |
CSB-PA001783 | ATF4 Antibody | Human | WB, IHC, ELISA |
CSB-PA020024 | Phospho-ATF4 (S245) Antibody | Human | IHC, ELISA |
CSB-PA020025 | Phospho-ATF4 (S219) Antibody | Human,Mouse | WB, ELISA |
CSB-PA020026 | ATF4 Antibody | Human,Mouse | WB, ELISA |
CSB-PA038092 | ATF4 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA994815 | ATF4 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-RA002272A0HU | ATF4 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC, IP |
CSB-PA002272LA01HU | ATF4 Antibody | Human | ELISA, IHC, IF |
CSB-PA002272LB01HU | ATF4 Antibody, HRP conjugated | Human | ELISA |
CSB-PA002272LC01HU | ATF4 Antibody, FITC conjugated | Human | |
CSB-PA002272LD01HU | ATF4 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA002272LA11HU | ATF4 Antibody | Human | ELISA, WB, IHC |
CSB-PA002272LB11HU | ATF4 Antibody, HRP conjugated | Human | ELISA |
CSB-PA002272LC11HU | ATF4 Antibody, FITC conjugated | Human | |
CSB-PA002272LD11HU | ATF4 Antibody, Biotin conjugated | Human | ELISA |
ATF4 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA747361XA01DIL | atf4 Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
ATF4 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA880648ZA01RA | Atf4 Antibody | Rattus norvegicus | ELISA, WB (ensure identification of antigen) |
ATF4 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP002272MO CSB-EP002272MO CSB-BP002272MO CSB-MP002272MO CSB-EP002272MO-B |
Recombinant Mouse Cyclic AMP-dependent transcription factor ATF-4 (Atf4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATF4 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP002272HU CSB-EP002272HU CSB-BP002272HU CSB-MP002272HU CSB-EP002272HU-B |
Recombinant Human Cyclic AMP-dependent transcription factor ATF-4 (ATF4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATF4 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP669151BO CSB-EP669151BO CSB-BP669151BO CSB-MP669151BO CSB-EP669151BO-B |
Recombinant Bovine Cyclic AMP-dependent transcription factor ATF-4 (ATF4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATF4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP747361DIL CSB-EP747361DIL CSB-BP747361DIL CSB-MP747361DIL CSB-EP747361DIL-B |
Recombinant Danio rerio Cyclic AMP-dependent transcription factor ATF-4 (atf4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATF4 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP880648RA CSB-BP880648RA CSB-MP880648RA CSB-EP880648RA-B |
Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP880648RA | Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) | E.coli |
CSB-CF880648RA | Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) | in vitro E.coli expression system |