Neuregulin 1 (NRG1), also known as glial growth factor (GGF), is a regulatory and protective growth factor which belongs to neuregulin family. NRG1 was first discovered in the field of neuroscience research in 1992, and it can encode at least 15 different transmembrane protein structures by initiating different transcriptional promoters and selective mRNA splicing. Currently, there are four main subtypes, including type I NRG1-type IV NRG1. Among of them, type I-type III three different NRG1 subtypes are the most important.
NRG1 is the main ligand of ERBBs and initiates a complex intracellular signaling cascade through the NRG1/ERBBs. NRG1/ERBB activates extracellular signal-regulated kinases (ERK), phosphatidylinositol 3-kinases (PI3Ks), serine/threonine protein kinases (AKT), mitogen-activated protein kinase (MAPK), protein kinase C (PKC), Janus kinase signal and signal transducer and activator of transcription (JAK-STAT). NRG1 is involved in the activation of these signaling pathways, which affects proliferation, differentiation and anti-apoptotic activities in cells.
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Validated Data
Greater than 95% as determined by SDS-PAGE.
Immobilized NRG1 at 2 μg/ml can bind human ERBB3 (CSB-MP007765HU), the EC50 is 18.24-23.66 ng/ml.
The following Nrg1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Nrg1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA016077GA01HU | NRG1 Antibody |
Human,Mouse | ELISA,WB,IHC |
CSB-PA005465 | NRG1 Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA970558 | NRG1 Antibody |
Human | ELISA,WB |
CSB-PA940332 | NRG1 Antibody |
Human,Mouse | ELISA,WB,IHC |
CSB-PA965247 | NRG1 Antibody |
Human | ELISA,WB |
CSB-PA09589A0Rb | NRG1 Antibody |
Human | ELISA, IHC, IF |
CSB-PA09589B0Rb | NRG1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA09589C0Rb | NRG1 Antibody, FITC conjugated |
Human | |
CSB-PA09589D0Rb | NRG1 Antibody, Biotin conjugated |
Human | ELISA |
Nrg1 Antibodies for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA966535XA01CZD | NRG1 Antibody |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) | ELISA, WB (ensure identification of antigen) |
Nrg1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA911352XA01SVG | NRG1 Antibody |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
Nrg1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP526051XBE CSB-EP526051XBE CSB-BP526051XBE CSB-MP526051XBE CSB-EP526051XBE-B |
Recombinant Xenopus laevis Pro-neuregulin-1, membrane-bound isoform (nrg1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Nrg1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-AP002851HU | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active) |
E.coli |
CSB-AP002861HU | Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (NRG1), partial (Active) |
E.Coli |
CSB-AP002921HU | Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (NRG1),Partial (Active) |
E.coli |
CSB-AP005731HU | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active) |
E.coli |
CSB-MP016077HU1(F6) | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active) |
Mammalian cell |
CSB-EP016077HU1 | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial |
E.coli |
Nrg1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF016077RA | Recombinant Rat Pro-neuregulin-1, membrane-bound isoform (Nrg1) |
in vitro E.coli expression system |
CSB-YP016077RA1 CSB-EP016077RA1 CSB-BP016077RA1 CSB-MP016077RA1 CSB-EP016077RA1-B |
Recombinant Rat Pro-neuregulin-1, membrane-bound isoform (Nrg1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |