PIK3R2 Research Reagents

Phosphatidylinositol 3-kinase regulatory subunit beta is a protein in humans that is encoded by PIK3R2 gene. Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

The following PIK3R2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PIK3R2 Antibodies

PIK3R2 Antibodies for Homo sapiens (Human)

PIK3R2 Proteins

PIK3R2 Proteins for Bos taurus (Bovine)

PIK3R2 Proteins for Mus musculus (Mouse)

PIK3R2 Proteins for Homo sapiens (Human)

PIK3R2 Proteins for Rattus norvegicus (Rat)

PIK3R2 Background

Phosphatidylinositol 3-kinase regulatory subunit beta is a protein in humans that is encoded by PIK3R2 gene. It is a regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

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