PIK3R2 Antibody

Datasheet
Code CSB-PA797994
Former Code(s) CSB-PA777948
Size US$299
Uniprot No. O00459
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using CSB-PA797994(PIK3R2 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA797994(PIK3R2 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Raji cells, A549 cells, A431 cells, K562 cells, Primary antibody: CSB-PA797994(PIK3R2 Antibody) at dilution 1/233, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human PIK3R2
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC;ELISA:1:2000-1:5000,WB:1:200-1:1000,IHC:1:50-1:100
Relevance Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Immunogen Species Homo sapiens (Human)
Target Names PIK3R2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy
Involvement in disease Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1)
Protein Families PI3K p85 subunit family
Database Links

HGNC: 8980

OMIM: 603157

KEGG: hsa:5296

STRING: 9606.ENSP00000471914

UniGene: Hs.371344

Pathway cAMP signaling pathway
Chemokine signaling pathway
ErbB signaling pathway
Estrogen signaling pathway
HIF-1 signaling pathway
Jak-STAT signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Regulation of actin cytoskeleton
TNF signaling pathway
Apoptosis
Autophagy
Cellular senescence
Ras signaling pathway
Signaling pathways regulating pluripotency of stem cells
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Natural killer cell mediated cytotoxicity
Osteoclast differentiation
T cell receptor signaling pathway
Toll-like receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications
AMPK signaling
FoxO signaling pathway
Insulin signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Rap1 signaling pathway
Sphingolipid signaling pathway
Neurotrophin signaling pathway

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