PIK3R2 Antibody

Datasheet
Code CSB-PA080215
Size US$167
Uniprot No. O00459
Image
  • Immunohistochemical analysis of paraffin-embedded human breast caricnoma using PI 3-Kinase p85β Polyclonal Antibody.

  • Western blot analysis of HepG2 using PI 3-Kinase p85β Polyclonal Antibody.

Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Protein
Raised in Rabbit
Species Reactivity Human
Tested Applications WB,IHC;WB:1:1000-2000.IHC:1:50-200
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Isotype IgG
Alias Phosphatidylinositol 3-kinase regulatory subunit beta
Immunogen Species Homo sapiens (Human)
Target Names PIK3R2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy
Involvement in disease Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1)
Protein Families PI3K p85 subunit family
Database Links

HGNC: 8980

OMIM: 603157

KEGG: hsa:5296

STRING: 9606.ENSP00000471914

UniGene: Hs.371344

Pathway cAMP signaling pathway
Chemokine signaling pathway
ErbB signaling pathway
Estrogen signaling pathway
HIF-1 signaling pathway
Jak-STAT signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Regulation of actin cytoskeleton
TNF signaling pathway
Apoptosis
Autophagy
Cellular senescence
Ras signaling pathway
Signaling pathways regulating pluripotency of stem cells
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Natural killer cell mediated cytotoxicity
Osteoclast differentiation
T cell receptor signaling pathway
Toll-like receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications
AMPK signaling
FoxO signaling pathway
Insulin signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Rap1 signaling pathway
Sphingolipid signaling pathway
Neurotrophin signaling pathway

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