PIK3R2 Antibody

Datasheet
Code CSB-PA030060
Size US$167
Uniprot No. O00459
Immunogen Synthesized peptide derived from the Internal region of Human PI 3-kinase p85β.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications IHC,ELISA;IHC:1/100-1/300.ELISA:1/10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias PIK3R2; Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PI3-kina
Immunogen Species Homo sapiens (Human)
Protocols Immunohistochemistry (IHC) Protocol
ELISA Protocol
Target Names PIK3R2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy
Involvement in disease Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1)
Protein Families PI3K p85 subunit family
Database Links

HGNC: 8980

OMIM: 603157

KEGG: hsa:5296

STRING: 9606.ENSP00000471914

UniGene: Hs.371344

Pathway cAMP signaling pathway
Chemokine signaling pathway
ErbB signaling pathway
Estrogen signaling pathway
HIF-1 signaling pathway
Jak-STAT signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Regulation of actin cytoskeleton
TNF signaling pathway
Apoptosis
Autophagy
Cellular senescence
Ras signaling pathway
Signaling pathways regulating pluripotency of stem cells
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Natural killer cell mediated cytotoxicity
Osteoclast differentiation
T cell receptor signaling pathway
Toll-like receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications
AMPK signaling
FoxO signaling pathway
Insulin signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Rap1 signaling pathway
Sphingolipid signaling pathway
Neurotrophin signaling pathway

Related Products

PIK3R2 Antibodies

PIK3R2 Antibodies for Homo sapiens (Human)

PIK3R2 Antibodies for Human

PIK3R2 Proteins

PIK3R2 Proteins for Homo sapiens (Human)

PIK3R2 ELISA Kit

PIK3R2 ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.