PIK3R2 Antibody

^Datasheet

Specification
Target

Code	CSB-PA018005LA01HU
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Size	US$299Purchase it in Cusabio online store (only available for customers from the US)
Uniprot No.	O00459
Image	Western Blot Positive WB detected in: Jurkat whole cell lysate All lanes: PIK3R2 antibody at 4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 82 kDa Observed band size: 82 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA018005LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA018005LA01HU at dilution of 1:100
Immunogen	Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit beta protein (75-125AA)
Raised in	Rabbit
Species Reactivity	Human
Tested Applications	ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200
Relevance	Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
Form	Liquid
Conjugate	Non-conjugated
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method	>95%, Protein G purified
Isotype	IgG
Clonality	Polyclonal
Alias	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta), PIK3R2
Immunogen Species	Human
Protocols	ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol
Research Area	Signal Transduction
Target Names	PIK3R2
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function	Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy
Involvement in disease	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1)
Protein Families	PI3K p85 subunit family
Database Links	HGNC: 8980 OMIM: 603157 KEGG: hsa:5296 STRING: 9606.ENSP00000471914 UniGene: Hs.371344
Pathway	cAMP signaling pathway Chemokine signaling pathway ErbB signaling pathway Estrogen signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Focal adhesion Regulation of actin cytoskeleton TNF signaling pathway Apoptosis Autophagy Cellular senescence Ras signaling pathway Signaling pathways regulating pluripotency of stem cells B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Natural killer cell mediated cytotoxicity Osteoclast differentiation T cell receptor signaling pathway Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications AMPK signaling FoxO signaling pathway Insulin signaling pathway Phosphatidylinositol signaling system Phospholipase D signaling pathway Rap1 signaling pathway Sphingolipid signaling pathway Neurotrophin signaling pathway

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PIK3R2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP018005HU CSB-EP018005HU CSB-BP018005HU CSB-MP018005HU	Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit beta(PIK3R2)	Yeast E.coli Baculovirus Mammalian cell

PIK3R2 ELISA Kit

PIK3R2 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL018005HU	Human Phosphatidylinositol 3-kinase regulatory subunit beta(PIK3R2) ELISA kit	serum, plasma, tissue homogenates, cell lysates	5.86 pg/mL

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PIK3R2 Antibody

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