Recombinant Human Interleukin-7 protein(IL7) (Active)

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Code CSB-AP001751HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine 2E8 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
Target Names IL7
Uniprot No. P13232
Research Area Immunology
Alternative Names IL 7; IL-7; Il7; IL7_HUMAN; Interleukin 7; Interleukin-7; LP-1; Lymphopoietin 1
Species Homo sapiens (Human)
Source E.coli
Expression Region 26-177aa
Mol. Weight 17.4 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
Gene References into Functions
  1. Human IL-7 binds more strongly to stretched than to relaxed Fibronectin. PMID: 28845674
  2. Downregulation of IL-7 and T follicular helper cells (Tfh) might contribute to viral persistence in hepatitis C virus (HCV)infection. The in vitro study revealed an immunopotentiator of IL-7 in chronic HCV infection, which manifested as IL-7-regulated HCV-specific and nonspecific activated Tfh cells. PMID: 29672235
  3. These data indicate the involvement of IL-7 into a direct upregulation of growth and functional activity of human T cells in the absence of antigenic stimulus and the relative scarcity of costimulatory effects. PMID: 30193429
  4. these findings add further evidence that IL-7 is a key regulatory factor that may tune the balance between functionally different T-cell subsets following haematopoietic stem cell transplantation PMID: 29033080
  5. The constitutively signaling C7R system developed here delivers potent IL7 stimulation to CAR T cells, increasing their persistence and antitumor activity against multiple preclinical tumor models, supporting its clinical development PMID: 28830878
  6. we demonstrated that Imatinib mesylate (IM)impaired T cell survival through the inhibition of IL-7 and STAT5-p but not TCR signaling which remained unaffected during IM therapy. Thus, off-target inhibitory effects of IM on IL-7 and STAT5-p explain how T cell lymphopenia occurs in patients treated with IM. PMID: 28387753
  7. In this study, authors compared the concentrations of IL-15 and IL-7 in the plasma of MDS patients (n = 20) compared with that in the plasma of healthy controls (n = 20). PMID: 27036031
  8. Data strongly implicate IL-7 in the thymus-independent long-term survival of functional naive-Tregs. PMID: 26910841
  9. the critical role played by IL-7 and IL-15 in T cell homeostasis and how these cytokines could be used to improve immune reconstitution after allogeneic SCT. PMID: 26795458
  10. IL-7/IL-7R signaling pathway plays a possible role in recurrent pregnancy loss by upregulating Th17 immunity while downregulating Treg immunity. PMID: 27767237
  11. IL-7 inhibits the osteogenic differentiation of Periodontal ligament stem cells probably via inactivation of mitogen-activated protein kinase (MAPK) signaling pathway. PMID: 27579861
  12. this study shows that IL-7 restores T Lymphocyte immunometabolic failure in septic shock patients through mTOR activation PMID: 28724580
  13. In CRC, IL-7 was higher in patients with lymph node and distant metastases and with tumors located in right colon. In adenomas, IL-7 elevation was associated exclusively with villous growth pattern, while in IBD, circulating IL-7 reflected clinical activity of Crohn's disease and ulcerative colitis. PMID: 27866242
  14. Tuberculosis patients had lower soluble IL-7R and higher IL-7 plasma concentrations as compared to healthy contacts. PMID: 28582466
  15. CD56(bright) NK IL-7Ralpha expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections PMID: 28400540
  16. IL-7 has a role inducing epitope masking of gammac protein in IL-7 receptor signaling complex PMID: 28127156
  17. Therefore, generalized CD8+ T-cell impairment in HCV infection is characterized, in part, by impaired IL-7-mediated signalling and survival, independent of CD127 expression. This impairment is more pronounced in the liver and may be associated with an increased potential for apoptosis. This generalized CD8+ T-cell impairment represents an important immune dysfunction in chronic HCV infection that may alter patient health. PMID: 27315061
  18. These results reveal a novel role of IL-7 and IL-15 in maintaining human T cell function, provide an explanation for T cell dysfunction in humanized mice, and have significant implications for in vitro studies with human T cells. PMID: 27855183
  19. The results show that SNPs in IL7 caused a significant association in this OA Chinese Han population. PMID: 27235388
  20. IL-7 is capable of enhancing functional T cell activity without causing significant functional inbalance between various T cell subsets. PMID: 28396296
  21. In summary, our study demonstrates that IL-7/IL-7R axis promotes the invasion and migration of prostate cancer cells, through activation of AKT/NF-kappaB pathway and upregulation of MMP-3 and MMP-7 expression PMID: 27611862
  22. review of role of IL-7 in immunity and its role in the pathogenesis of neoplasia [review] PMID: 28314253
  23. Indian patients with primary Sjogren's syndrome have higher salivary sL-selectin and IL-7 levels than healthy controls PMID: 27620619
  24. increased IL-7 was secreted by mesenchymal stem cells (MSC) in the bone marrow, which may protect leukemic cells from apoptosis induced by imatinib through JAK1/STAT5 signaling pathway PMID: 27272942
  25. The results from this study suggested for the first time that miR-181c was able to negatively regulate the production of proinflammatory cytokines IL-7 and IL-17 in myasthenia gravis patients. PMID: 25962782
  26. Increase in serum IL-7 is associated with adenoma. PMID: 25793917
  27. provides negative feedback on its own signaling in T cells via endocytosis and degradation of its receptor, CD127 PMID: 26272555
  28. Observed highly significant reductions in the concentration of circulating interleukin (IL)-16, IL-7, and Vascular Endothelial Growth Factor A (VEGF-A) in encephalomyelitis/chronic fatigue syndrome patients. PMID: 26615570
  29. The observations suggest that IL-7 may play a role in the pathogenesis of Graves' disease and may be associated with its clinical activity. PMID: 26113403
  30. IL-7 and SCF are elevated for a prolonged period after double umbilical cord blood transplantation and persistently high levels of these cytokines may correlate with worse clinical outcomes. PMID: 26177551
  31. IL7 was expressed primarily in the infundibulum and suprabulb of the hair follicle. IL7 expression was increased in cutaneous T-cell lymphoma. PMID: 26479922
  32. this study identified that IL-7, as well as the Akt/ mTOR signaling pathway, effectively modulates human Double-Negative T Cell- mediated suppression of allogeneic T cell responses. PMID: 26324773
  33. IL-7/IL-17 axis mediates chronic pelvic pain in experimental autoimmune prostatitis and in patients. PMID: 25933188
  34. In view of the important role IL-7 plays in lymphocyte proliferation, homeostasis and survival, down regulation of CD127 by Tat likely plays a central role in immune dysregulation and CD4 T-cell decline PMID: 25333710
  35. decreased IL-7 in peripheral blood, maybe, is a consequence of the negative feedback of the pro-inflammatory function in ITP patients. PMID: 24750122
  36. Septic patients showed the lowest levels of IL-7. Patients with severe sepsis reached levels of IL-7 higher than those observed in the groups of uncomplicated sepsis and septic shock. PMID: 25169828
  37. These observations provide evidence of a novel mechanism that enables cells to optimally use IL-7. PMID: 25870237
  38. blocking IL-7 in hMSCs-lymphocytes co-cultures increased lymphocytes apoptosis and we also have demonstrated that hMSCs are able to produce this interleukin PMID: 25184791
  39. The present data indicate that high plasma levels of IL-7 in the early post-transplant period are predictive for slow T cell reconstitution, increased risk of acute graft-versus-host disease and increased mortality following haematopoietic stem cell transplantation. PMID: 25263171
  40. IL-7 elevates miR-124 to decrease the expression of splicing regulator PTB and represses CD95 mRNA splicing. PMID: 25411246
  41. These results strongly suggest that IL-7/IL-7R prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax PMID: 24695377
  42. These data suggest that increased IFN-alpha activity may promote the loss of T cells by accelerating cell turnover and activation-induced cell death while decreasing the renewal of T cells by inhibiting the proliferative effect of IL-7. PMID: 25063872
  43. Diminished T-cell responsiveness to IL-7. PMID: 24585897
  44. Low-level transient antigenic stimuli during cART were not associated with changes in the thymic function or the IL-7/CD127 system. PMID: 24820104
  45. IL-7 can have a significant impact in sustaining expansion and persistence of adoptively chimeric antigen receptor-redirected cytotoxic T lymphocytes. PMID: 24097874
  46. IL-23 does not induce IL-7 expression in microglia and astrocytes. PMID: 24224652
  47. Changes of IL-7 expression in different phases of Graves ophthalmopathy (GO) suggested that IL-7 may play an important role in the pathogenesis of GO. PMID: 23188693
  48. These results suggest that ineffective responses to IL-7 could impair the transition to memory cells of naive CD4(+) T lymphocytes recognizing self-peptides in the setting of strong costimulation. PMID: 23454917
  49. our data point toward an unexpected new role for IL-7 as a potential autocrine mediator of lymphatic drainage PMID: 23963040
  50. our data show that IL-7 negatively regulates Tregs PMID: 23966629
  51. KGF could up-regulate IL-7 expression through the STAT1/IRF-1, IRF-2 signaling pathway, which is a new insight in potential effects of KGF on the intestinal mucosal immune system. PMID: 23554911
  52. genetic, immunologic, and metabolic factors contribute to a dysregulation of the IL-7/IL-7 receptor pathway in type 1 diabetes and identify a novel hyperglycemia-mediated interference of immune regulatory networks. PMID: 23454692
  53. IL-7 levels were significantly lower in patients with Crohn's disease than in controls. PMID: 22314878
  54. IL-7 and IL-15 levels remain relatively low after nonmyeloablative transplantation. PMID: 23437070
  55. Increase in the level of IL-7 is associated with skin pathogenesis in breast cancer. PMID: 23244154
  56. In conclusion the positive correlation between plasma concentration of IL-7, MCP-1 and hs-CRP in diabetic foot patients observed herein, suggests a plausible role for IL-7 in the promotion of clinical instability in coronary artery disease PMID: 22921903
  57. The importance of optimal IL-7 and pre-TCR signaling during adult human T cell development, was investigated. PMID: 22897934
  58. Data show that lymphatic endothelial cells (LECs) are a prominent source of IL-7 both in human and murine lymph nodes. PMID: 22955921
  59. IL-7/IL-7R promotes c-Fos/c-Jun expression and activity in non-small cell lung cancer which further facilitates cyclin D1 expression, and accelerates proliferation of cells and VEGF-D-induced lymphovascular formation. PMID: 23157741
  60. IL-7 or IL-15 priming of the RasGRP/SOS pathway contributes to the increased ERK responsiveness and reduces the threshold above which signaling cascades are initiated, thereby predisposing for autoimmunity. PMID: 23325887
  61. IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. PMID: 23160470
  62. IL-7-rich environment abrogates regulatory T (Treg) cell suppressor function and promotes activation and expansion of T effector cells, alloreactive and autoreactive T cells, and Tregs, all of which become fully functional cell populations. PMID: 23129754
  63. Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo. PMID: 22949940
  64. Data indicate that serum IL-7 was confirmed as independent variable associated to both disease-free survival (DFS) and overall survival (OS). PMID: 22795293
  65. Expression of IL-7 and its receptor was significantly elevated in rheumatoid arthritis (RA) synovial fluid and peripheral blood macrophages as well as RA fibroblasts, compared to normal cells. PMID: 21647866
  66. the first report of rhIL-7 ability to restore normal lymphocyte functions in septic patients. PMID: 23053510
  67. Hepatocyte-derived transgenic IL-7 plays an indispensable role in maintenance of natural killer T (NKT) and T cells in adult mouse liver and development of B cells in fetal liver. PMID: 23018454
  68. analysis of synergistic effects of interleukin-7 and pre-T cell receptor signaling in human T cell development PMID: 22859301
  69. In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID: 22506826
  70. these findings demonstrate that IL-7delta5 variant induces human breast cancer cell proliferation and cell cycle progression via activation of PI3K/Akt pathway. PMID: 22618230
  71. JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction PMID: 22384197
  72. IL-7 gene expression was similar in controls and bacteraemia, but lower in sepsis patients. PMID: 21711552
  73. IL-7 and TGFbeta1 are promising markers to indicate those at risk for poor prostate cancer survival. PMID: 22113713
  74. We did not observe differences in thymic function, but we found that plasma levels of interleukin-7 and the frequency of its receptor were significantly decreased in preterm infants PMID: 22398700
  75. Considering the immunostimulatory ability of IL-7Ralpha T cells and IL-7, this suggests that IL-7(R)-dependent T cell-driven immune activation plays an important role in inflammation in Sjogren syndrome. PMID: 22312161
  76. After seven years of effective highly active antiretroviral therapy, the quantity and capacity of T cell subsets and IL-7 in HIV-1-infected patients had been partially restored. PMID: 22027639
  77. IL-7 was significantly increased in the serum of patients with active Vogt Koyanagi-Harada disease compared with those without or with inactive Vogt Koyanagi-Harada disease. PMID: 22247488
  78. a serum profile of high IL-7 may signify a T(H)1-driven form of MS PMID: 21795588
  79. In HIV patients with low or moderate degree of immunodeficiency, CD4 counts and plasma IL-7 levels do not evolve in parallel, suggesting that other factors different from CD4 counts must be involved in the upregulation of IL-7 observed in HIV infection. PMID: 21876448
  80. HIV infection of thymocytes inhibits IL-7 activity. PMID: 21920046
  81. relationship between CD127 expression, IL-7 signaling and Ig gene rearrangement in pre-B cells PMID: 21680796
  82. the existence of a critical crosstalk between PI3K/Akt signaling pathway and ROS that is essential for IL-7-mediated T-ALL cell survival PMID: 21455214
  83. IL-7 dysregulation and loss of CD8+ T cell homeostasis in the monogenic human disease autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. PMID: 21753149
  84. immunological nonresponders to HIV therapy display elevated BM IL-7/IL-7Ralpha expression but impaired T-cell responsiveness to IL-7, suggesting the activity of a central compensatory pathway targeted to replenish the CD4+ compartment PMID: 21209878
  85. CD4 T cell subsets from patients with HIV infection show enhanced signal transducer-activator of transcription (STAT)1 phosphorylation in response to exogenous IL-7. PMID: 21257970
  86. Increased amounts of bioavailable IL-7 are not detected in the spleens of transgenic IL-7 receptor alpha449F mice because IL-7Ralpha-expressing cells that bind IL-7 are acting as a cytokine sink. PMID: 21239710
  87. The high expression of IL-7 and IL-7R is highly positie correlated with clinic stage, lymph node metastasis, VEGF-D, LVD and poor prognosis in Non-small cell lung cancer. PMID: 21159243
  88. A large favorable entropy change, a global favorable electrostatic component, and glycosylation of the receptor, albeit not at the interface, contribute significantly to the interaction between IL-7 and the IL-7R subunit alpha extracellular domain. PMID: 20815339
  89. bone-invading cells express and produce IL-7, which is known to promote osteoclast activation and osteolytic lesions PMID: 20067635
  90. Interleukin-7 enhances memory CD8(+) T-cell recall responses in health but its activity is impaired in human immunodeficiency virus infection. PMID: 20673240
  91. Subjects with major depressive disorder had low serum levels of IL7. May underlie the depression-related impairment of T-cell function. PMID: 20382196
  92. enhances survival of CD56bright NK cells PMID: 20386468
  93. Transgenic expression of IL-7 restores a protective anti-pneumococcal polysaccharide response in young mice. PMID: 20505146
  94. IL-7 protects human CD4+ effector/memory T cells from apoptosis. IL-7 upregulates not only Bcl-2, but also Bcl-xL and Mcl-1. Il-7 activates the JAK/STAT signalling pathway. PMID: 20465565
  95. The IL-7 transcript, lacking exon 4, and not the full length IL-7 represents the dominant IL-7 RNA transcript in human PBMCs and a novel IL-7R splice variant lacking exons 5, 6 and 7. PMID: 20226540
  96. IL-7 controls glucose utilization by regulating the gene expression of HXKII, suggesting a mechanism by which IL-7 supports bioenergetics that control cell fate decisions in lymphocytes. PMID: 20200205
  97. early events leading to IL-7 signal transduction involve its receptor compartmentalization into membrane nanodomains and cytoskeleton recruitment PMID: 20167604
  98. findings suggest that polymorphism of IL-17F 7488 involved in susceptibility to gastric cancer, which also influenced certain subtypes according to clinicopathological features, whereas IL-17A 197 may be less relevant PMID: 19904747
  99. IL-7 triggers rapid IL-7Ralpha endocytosis, which is required for IL-7-mediated signaling and subsequent receptor degradation PMID: 20190194
  100. Data demonstrate that IL-7 is a novel myokine regulated both in vitro and in vivo, and it may play a role in the regulation of muscle cell development. PMID: 20089933

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Subcellular Location Secreted
Protein Families IL-7/IL-9 family
Database Links

HGNC: 6023

OMIM: 146660

KEGG: hsa:3574

STRING: 9606.ENSP00000263851

UniGene: Hs.591873

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