Recombinant Rhesus Macaque Interleukin-13 protein (IL13) (Active)

IL-13 is a key Th2 cytokine driving alternative macrophage activation, IgE class switching, and airway inflammation, making a reliable rhesus macaque ortholog essential for translational immunology in nonhuman primate models. This tag-free recombinant protein encompasses the full-length mature sequence (residues 19–132) and demonstrates strong signaling potency, with an ED50 below 5 ng/mL in a TF-1 cell proliferation assay corresponding to a specific activity exceeding 2.0 × 10⁵ IU/mg — providing a suitable basis for cell-based functional assays including proliferation, differentiation, and JAK/STAT pathway activation studies. Endotoxin levels below 1.0 EU/μg minimize LPS-driven artifacts in sensitive immune cell experiments, supporting use in primary cell cultures and in vivo primate models of allergic inflammation or asthma. Purity exceeding 98% by SDS-PAGE, combined with this endotoxin profile, also aligns with standards expected in antibody development workflows and as a reference standard in cytokine detection assays.