SERPINE1 Antibody

Datasheet
Code CSB-PA021081GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. P05121
Immunogen Human SERPINE1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1;SERPINE1;PAI;PAI-1;PAI1;PLANH1 ;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Cardiovascular
Target Names SERPINE1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
HGNC 8583
RGD 3249
MGI 97608
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Function Serine protease inhibitor. Inhibits TMPRSS7
Involvement in disease Plasminogen activator inhibitor-1 deficiency (PAI-1D)
Subcellular Location Secreted
Protein Families Serpin family
Tissue Specificity Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Database Links

HGNC: 8583

OMIM: 173360

KEGG: hsa:5054

STRING: 9606.ENSP00000223095

UniGene: Hs.414795

Pathway HIF-1 signaling pathway
Hippo signaling pathway
p53 signaling pathway
Cellular senescence
Complement and coagulation cascades
AGE-RAGE signaling pathway in diabetic complications
Apelin signaling pathway

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