Recombinant Human Complement receptor type 2(CR2) ,partial

Code CSB-YP005934HU
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Source Yeast
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Code CSB-EP005934HU
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Source E.coli
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Code CSB-EP005934HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005934HU
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Source Baculovirus
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Code CSB-MP005934HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CR2
Uniprot No. P20023
Alternative Names C3DR; CD 21; CD21; Complement C3d receptor 2; Complement C3d receptor; Complement component (3d/Epstein Barr virus) receptor 2; Complement receptor type 2; CR; Cr2; CR2_HUMAN; CVID7; EBV receptor; EBV-R; Epstein Barr virus receptor; Epstein-Barr virus receptor; EVBR; SLEB9
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU. Participates in B lymphocytes activation.; (Microbial infection) Acts as a receptor for Epstein-Barr virus.
Gene References into Functions
  1. This study shown the C3d+ microglial clusters were found in chronic but not acute multiple sclerosis. PMID: 27778395
  2. This study uncovers the origin of the effect of ionic strength on C3d-CR2 interaction and deepens the understanding of the molecular mechanism of their interaction, which is valuable for the design of vaccines and small molecule inhibitors. PMID: 27154286
  3. Binding of PF4/heparin complexes to B cells is mediated through the interaction between complement and complement receptor 2. PMID: 27412887
  4. high pERK expression and accelerated apoptosis revert within 4 weeks after beginning therapy, whereas clonal B cells unresponsive to TLR9 stimulation persist for at least 24 weeks, although they may partially rescue normal CD21 expression. PMID: 28507081
  5. Cerebrospinal fluid (CSF) soluble complement receptor 2 (sCR2) levels correlated significantly both with CSF complements C3 and C1q as well as to a disease severity measure. PMID: 27085202
  6. CR2 contributes to human Osteonecrosis of the femoral head susceptibility in Korean systemic lupus erythematosus patients. PMID: 27446959
  7. In this study, we have shown that the CR2 +24T>C polymorphism is not a risk marker for nasopharyngeal carcinoma development in the North region of Portugal. PMID: 26748973
  8. In mature B cells, CD21 transcription proceeds from a focused transcriptional start site regulated by a non-consensus TATA box, an initiator element and a downstream promoter element. PMID: 25640655
  9. Reduced expression of CD21 on CLL B-cells appears functionally relevant and was associated with poor clinical outcomes. PMID: 26452134
  10. These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to systemic lupus erythematosus. PMID: 25180293
  11. repression of the CR2/CD21 promoter can occur through one of the E-box motifs via recruitment of RP58. PMID: 25817480
  12. found that the protective CR2 genotype is correlated with lower levels CR2 mRNA as well as differences in the ratio of the long and short CR2 isoforms PMID: 25569262
  13. The paradoxical enhancement of immune responses by C3d in the absence of CD21 is due to internalization and processing of C3d into peptides that activate autoreactive CD4(+) T-helper cells. PMID: 25385064
  14. Higher C3d/C3 ratios were found for current smoker, higher age, age-related macular degeneration phenotype, and the two SNPs in the C3 gene, rs6795735 and rs2230199. PMID: 24675670
  15. Authors show that expression of the Epstein-Barr virus B-cell attachment receptor, CD21, in B cells that lack this receptor results in significant changes in gene expression, both before and rapidly following EBV-CD21 interaction. PMID: 24600013
  16. Our findings implicate CR2 as a susceptibility gene for nasopharyngeal carcinoma and suggest that enhanced CR2 expression may be involved in the oncogenesis and development of nasopharyngeal carcinoma. PMID: 23612877
  17. To eradicate this virus, targeting CD21 on these EBV-infected B cells is hypothesized here. PMID: 23384704
  18. Patients with primary Sjogren's Syndrome who display high frequencies of autoreactive and unresponsive CD21-/low B cells are susceptible to developing lymphoproliferation. PMID: 23279883
  19. plasma sCD21 levels are higher, while B-cell surface CD21 expression levels are lower in B-cell chronic lymphocytic leukemia (B-CLL) patients, but not in multiple myeloma (MM) patients. PMID: 22899340
  20. Transgenic mice inoculated with elk brain homogenate expressing high levels of prion (PrPC) protein die of chronic wasting disease. PMID: 23002439
  21. All subtypes of juvenile arthritis have reduced circulating levels of sCD21 and sCD23. PMID: 21328056
  22. These results suggest that CR2 plays a role in the recognition of foreign DNA during host-immune responses PMID: 22885687
  23. the 5' UTR is a novel regulatory element for the CR2 gene in which variation may alter gene function and modify the development of Systemic lupus erythematosus PMID: 22673213
  24. Prevalence of pulmonary fibrosis in patients with diffuse cutaneous systemic sclerosis inversely correlates with soluble cluster of differentiation 21 (sCD21) levels. PMID: 21052675
  25. Marginal zone B cells activated by hepatitis C virus undergo functional exhaustion associated with BCR signaling defects and overexpression of a key antiproliferative gene, and may subsequently become terminally spent CD21(low) B cells. PMID: 22678901
  26. CD21 expression is altered in multiple sclerosis (MS) patients as in other autoimmune diseases, although no evidence is found for a specific role of the CD21 gene in MS. PMID: 22137275
  27. Patients with hepatitis C virus infection who display high frequencies of unresponsive CD21(-/low) marginal zone B cells are more susceptible to developing autoimmunity and/or lymphoproliferation. PMID: 22084433
  28. CD23 oligomers appear more important in enhancing IgE synthesis and monomers lacking the tail residues fail to bind CD21 yet bind membrane IgE and down-regulate IgE synthesis. PMID: 21889131
  29. study reports a cocrystal structure of a CR2(SCR1-2):C3d complex at 3.2 angstrom resolution in which the interaction interfaces differ markedly from the previously published structure and are consistent with the biochemical data PMID: 21527715
  30. The impact of hCR2 expression on mouse B cell development and the baseline immunological status of the mice, was evaluated. PMID: 21269698
  31. Binding between Epstein Barr virus-transformed B cell line-derived exosomes and viral structural protein gp350 is dependent on CD21 expressed on the B cells. PMID: 21106852
  32. Molecular modeling approaches used to investigate disparities between the biochemical data and the X-ray structure of the CR2-C3d cocrystal result in highest-scoring solutions in which CR2 SCR1-2 is docked within the concave surface of C3d. PMID: 20951140
  33. Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair PMID: 20558730
  34. analysis of the physicochemical properties underlying C3d-CR2 association PMID: 20091675
  35. Staphylococcus aureus binder of Ig (Sbi) and complement receptor 2 (CR2) share overlapping binding sites on complement 3d (C3d), thus allowing the bacterial evasion molecule to block CR2 binding, thereby inhibiting the host's adaptive immune response. PMID: 20083651
  36. CR2-induced complement activation results in membrane depolarization, as indicated by annexin V binding, with kinetics similar to those of C3-fragment deposition and different from those of membrane attack complex formation. PMID: 19740327
  37. promoter activity is critically dependent on a cell type-specific repressor PMID: 11739509
  38. Redox control of EBV infection: prevention by thiol-dependent modulation of functional CD21/EBV receptor expression. PMID: 11813981
  39. crystal structure of human CD21; implications for epstein-barr virus and c3d binding PMID: 12122212
  40. The percentage of T cells expressing CD21 from all gestations was significantly higher than the adult and the percentage positive decreased with increasing gestational age. PMID: 12149502
  41. NF-kappaB signaling pathway enhances the expression of the CR2 gene, as a result of NF-kappaB proteins binding to two CR2 promoter elements. PMID: 12444129
  42. CR2 is shed mainly as a soluble CR2 complex, in which the CR2 units link covalently and react with nucleophilic agents PMID: 12713795
  43. Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation. PMID: 12813023
  44. Coligation of CD21 with the B cell antigen receptor lowers the antigen concentration threshold for eliciting protection from Fas apoptosis by 2-3 orders of magnitude. PMID: 14607925
  45. electrostatic calculations provide global and site-specific explanations of the physical causes that underlie the ionic strength dependence of C3d-CR2 association PMID: 15187133
  46. The activation of MAPKs is independently mediated by CR2 and that anti-CR2 McAb, PD98059, and Wortmanin block the activation of MAPKs, respectively. PMID: 15603708
  47. characterized the interaction between the first two short consensus repeats (SCR1-2) of complement receptor type 2 (CR2, CD21) and C3d PMID: 15713467
  48. the open V-shaped structures formed by CR2 SCR 1-2, both when free and when bound to C3d, are optimal for the formation of a tight two-domain interaction with its ligand C3d PMID: 15713468
  49. CD21 and CD23a are common targets for B lymphotropic gammaherpesviruses. PMID: 15795251
  50. Unresponsiveness to T-dependent antigen (sheep red blood cells) displayed by transgenic CR2-positive B cells is linked to increase in the stimulus level required to propel the B cell into a fully activated state, a normal humoral immune response. PMID: 15905540

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Involvement in disease Systemic lupus erythematosus 9 (SLEB9); Immunodeficiency, common variable, 7 (CVID7)
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Protein Families Receptors of complement activation (RCA) family
Tissue Specificity Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.
Database Links

HGNC: 2336

OMIM: 120650

KEGG: hsa:1380

UniGene: Hs.445757

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