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Proline-rich AKT1 substrate 1 is a protein in humans that is encoded by AKT1S1 gene. Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).
The following AKT1S1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
AKT1S1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA003848 | AKT1S1 Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA070015 | Phospho-AKT1S1 (T246) Antibody |
Human,Mouse,Rat | WB, ELISA |
| CSB-PA836185DSR2HU | AKT1S1 Antibody |
Human | ELISA, IHC |
| CSB-PA836185LA01HU | AKT1S1 Antibody |
Human, Rat | ELISA, WB, IHC |
| CSB-PA836185LD01HU | AKT1S1 Antibody, Biotin conjugated |
Human | ELISA |
AKT1S1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP836185HU CSB-EP836185HU CSB-BP836185HU CSB-MP836185HU CSB-EP836185HU-B |
Recombinant Human Proline-rich AKT1 substrate 1 (AKT1S1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AKT1S1 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP883972MO CSB-EP883972MO CSB-BP883972MO CSB-MP883972MO CSB-EP883972MO-B |
Recombinant Mouse Proline-rich AKT1 substrate 1 (Akt1s1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Proline-rich AKT1 substrate 1 is a protein in humans that is encoded by the AKT1S1 gene. AKT1S1 is a subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).
