Proline-rich AKT1 substrate 1 is a protein in humans that is encoded by AKT1S1 gene. Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).

AKT1S1 Antibodies

AKT1S1 Antibodies for Homo sapiens (Human)

AKT1S1 Antibodies for Human

AKT1S1 Proteins

AKT1S1 Proteins for Homo sapiens (Human)

AKT1S1 Proteins for Mus musculus (Mouse)

AKT1S1 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL836185HU1 AKT1S1 pUC NM_001098632.1
CSB-CL836185HU2 AKT1S1 pUC NM_001098633.2
CSB-CL836185HU3 AKT1S1 pUC NM_032375.4

AKT1S1 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL883972MO1 Akt1s1 pUC NM_001253920.1
CSB-CL883972MO2 Akt1s1 pUC NM_026270.4


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