AKT1S1

Proline-rich AKT1 substrate 1 is a protein in humans that is encoded by AKT1S1 gene. Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).

AKT1S1 Antibodies

AKT1S1 Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA003848 AKT1S1 Antibody Human,Mouse,Rat WB,IHC,ELISA
CSB-PA070015 Phospho-AKT1S1 (T246) Antibody Human,Mouse,Rat WB,ELISA
CSB-PA836185LB01HU AKT1S1 Antibody, HRP conjugated Human ELISA
CSB-PA836185LC01HU AKT1S1 Antibody, FITC conjugated Human ELISA
CSB-PA836185LD01HU AKT1S1 Antibody, Biotin conjugated Human ELISA

AKT1S1 Antibodies for Human

Code Product Name Species Reactivity Application
CSB-PA836185DSR2HU AKT1S1 Antibody Human ELISA, IHC
CSB-PA836185LA01HU AKT1S1 Antibody Human ELISA, IHC

AKT1S1 cDNA

AKT1S1 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL836185HU1 AKT1S1 pUC NM_001098632.1
CSB-CL836185HU2 AKT1S1 pUC NM_001098633.2
CSB-CL836185HU3 AKT1S1 pUC NM_032375.4

AKT1S1 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL883972MO1 Akt1s1 pUC NM_001253920.1
CSB-CL883972MO2 Akt1s1 pUC NM_026270.4

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