Human CD46, also known as membrane cofactor protein (MCP), belongs to the family of complement activation regulator (RCA) proteins and is a type I transmembrane glycoprotein that is expressed on most tissues as four major isoforms derived by alternative splicing of a single gene. CD46 is widely distributed on most of the normal cell surface, including hematopoietic cell lines, fibroblasts, epidermal cells, endothelial cells and stellate cells, but the number of cells expressed on different types of cells is Different.
CD46 is an intrinsic cofactor for the factor-I-mediated cleavage of C3b and C4b. Intrinsic refers to the fact that CD46 efficiently aids in cleaving C3b or C4b that is deposited on the same cell as CD46 itself. The cleavage of C3b produces the fragment C3bi, which is unable to support further complement activation. The cleavage of C4b by factor I and CD46 produces the fragments C4c and C4d. C4c is liberated into the extracellular milieu whereas C4d, incapable of continuing the complement cascade, remains attached to the target. CD46 is most effective in controlling the amplification loop of the alternative pathway. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization.
Additionally, CD46 also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
A large number of studies have demonstrated that CD46 is associated with a variety of immune-inflammatory diseases. Sandra et al. found that high expression of CD46 in people who have quit smoking prevent emphysema and chronic obstructive pulmonary disease caused by autoimmune and inflammatory reaction.
Currently, more than 60 disease-associated mutations in CD46 have now been identified. The majority of the mutations are linked to a rare thrombotic microangiopathic-based disease, atypical hemolytic uremic syndrome (aHUS), but new putative links to systemic lupus erythematosus, glomerulonephritis, and pregnancy-related disorders among others have also been identified.
So far, there are four drugs about CD46 in clinical trial, including Enadenotucirev (launched by PsiOxus Therapeutics, Merck Sharp & Dohme), Carcinoembryonic antigen-expressing measles virus (launched by National Cancer Institute), AugmAb (launched by BRIM Biotechnology, PAI Life Sciences) and FOR-46 (launched by University of California San Diego). Except Enadenotucirev, The research of other three drugs are at phase I, and Enadenotucirev is at phase II.
Regard reading: CD46, A Complement Regulator
Hot product of CD46:
Recombinant Human Membrane cofactor protein(CD46) (Active) (CSB-MP004939HU)The following Cd46 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Cd46 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004939LA01MO | Cd46 Antibody |
Mouse | ELISA, WB, IHC |
Cd46 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004939GA01HU | CD46 Antibody |
Human | ELISA,WB |
CSB-PA004939EA01HU | CD46 Antibody |
Human, Mouse | ELISA, WB, IHC |
CSB-PA004939EB01HU | CD46 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA004939EC01HU | CD46 Antibody, FITC conjugated |
Human | |
CSB-PA930156 | CD46 Antibody |
Human | ELISA,IHC |
CSB-PA923298 | CD46 Antibody |
Human | ELISA,IHC |
CSB-RA908548A0HU | CD46 Recombinant Monoclonal Antibody |
Human | ELISA, WB, IHC |
Cd46 Antibodies for Cavia porcellus (Guinea pig)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004939ZA01GU | CD46 Antibody |
Cavia porcellus | ELISA, WB (ensure identification of antigen) |
Cd46 Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP004939GU CSB-BP004939GU CSB-MP004939GU CSB-EP004939GU-B |
Recombinant Guinea pig Membrane cofactor protein (CD46), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP004939GU | Recombinant Guinea pig Membrane cofactor protein (CD46), partial |
E.coli |
CSB-CF004939GU | Recombinant Guinea pig Membrane cofactor protein (CD46) |
in vitro E.coli expression system |
Cd46 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP004939HU1 CSB-BP004939HU1 CSB-MP004939HU1 CSB-EP004939HU1-B |
Recombinant Human Membrane cofactor protein (CD46),partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004939HU | Recombinant Human Membrane cofactor protein (CD46) |
in vitro E.coli expression system |
CSB-MP004939HU | Recombinant Human Membrane cofactor protein (CD46), partial (Active) |
Mammalian cell |
Cd46 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP004939MO CSB-BP004939MO CSB-MP004939MO CSB-EP004939MO-B |
Recombinant Mouse Membrane cofactor protein (Cd46), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP004939MO | Recombinant Mouse Membrane cofactor protein (Cd46), partial |
E.coli |
CSB-CF004939MO | Recombinant Mouse Membrane cofactor protein (Cd46) |
in vitro E.coli expression system |
Cd46 Proteins for Saguinus mystax (Moustached tamarin)
Code | Product Name | Source |
---|---|---|
CSB-YP004939SWA CSB-EP004939SWA CSB-BP004939SWA CSB-MP004939SWA CSB-EP004939SWA-B |
Recombinant Saguinus mystax Membrane cofactor protein (CD46) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Cd46 Proteins for Saimiri sciureus (Common squirrel monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP004939SWD CSB-EP004939SWD CSB-BP004939SWD CSB-MP004939SWD CSB-EP004939SWD-B |
Recombinant Saimiri sciureus Membrane cofactor protein (CD46) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Cd46 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP735647PYX CSB-EP735647PYX CSB-BP735647PYX CSB-MP735647PYX CSB-EP735647PYX-B |
Recombinant Pongo abelii Membrane cofactor protein (CD46), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Cd46 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP740933BO CSB-EP740933BO CSB-BP740933BO CSB-MP740933BO CSB-EP740933BO-B |
Recombinant Bovine Membrane cofactor protein (CD46), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Cd46 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
Code | Product Name | Source |
---|---|---|
CSB-YP808496CYL CSB-EP808496CYL CSB-BP808496CYL CSB-MP808496CYL CSB-EP808496CYL-B |
Recombinant Callithrix jacchus Membrane cofactor protein (CD46), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Cd46 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-CF004939PI | Recombinant Pig Membrane cofactor protein (CD46) |
in vitro E.coli expression system |
CSB-YP004939PI1 CSB-EP004939PI1 CSB-BP004939PI1 CSB-MP004939PI1 CSB-EP004939PI1-B |
Recombinant Pig Membrane cofactor protein (CD46), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Cd46 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Code | Product Name | Source |
---|---|---|
CSB-CF004939DSU | Recombinant Chlorocebus aethiops Membrane cofactor protein (CD46) |
in vitro E.coli expression system |
CSB-YP004939DSU1 CSB-EP004939DSU1 CSB-BP004939DSU1 CSB-MP004939DSU1 CSB-EP004939DSU1-B |
Recombinant Chlorocebus aethiops Membrane cofactor protein (CD46), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Cd46 Proteins for Saguinus oedipus (Cotton-top tamarin)
Code | Product Name | Source |
---|---|---|
CSB-CF004939SWB | Recombinant Saguinus oedipus Membrane cofactor protein (CD46) |
in vitro E.coli expression system |
CSB-YP004939SWB1 CSB-EP004939SWB1 CSB-BP004939SWB1 CSB-MP004939SWB1 CSB-EP004939SWB1-B |
Recombinant Saguinus oedipus Membrane cofactor protein (CD46), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Cd46 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09216h | Human membrane cofactor protein,MCP ELISA Kit |
serum, plasma, tissue homogenates | 0.78 ng/mL |