Recombinant Human Complement receptor type 1(CR1),partial

Code CSB-EP005932HU
Size US$1726
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP005932HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CR1.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP005932HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CR1.
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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names CR1
Uniprot No. P17927
Alternative Names C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 including Knops blood group system; Complement component receptor 1; Complement receptor 1; Complement receptor type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen
Species Homo sapiens (Human)
Source E.coli
Expression Region 41-234aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 48.4kDa
Protein Length Partial
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Mediates cellular binding of particles and immune complexes that have activated complement.; FUNCTION
Gene References into Functions
  1. this study correlated phenotype data (CR1 density per erythrocyte (CR1/E), blood soluble CR1 (sCR1)) with genetic data (density/length polymorphisms) in AD patients and healthy controls.. PMID: 30044434
  2. CR1 rs1704660G, rs17047661G and rs6691117G variants were significantly associated with Chagas disease. PMID: 29323238
  3. Meta-analysis validated the association of late onset Alzheimer disease with CR1 (rs6656401) variants. PMID: 29504051
  4. rs6656401 CR1 is not associated with late-onset Alzheimer's disease. PMID: 28477215
  5. CR1 plays a vital role in Alzheimer's disease pathology and disease progression. PMID: 26742530
  6. the effect of CR1 rs3818361 polymorphism on Alzheimer's disease (AD) risk in Chinese cohorts is consistent with the increased risk observed in European AD cohorts. PMID: 26189835
  7. Genetic variation within the CR1 gene is associated with inflammation and the risk of incident coronary artery disease. PMID: 28033544
  8. The distribution of the CR1 alleles, genotypes and haplotypes differed significantly among population in Brazil, Vietnam, India, Republic of Congo and Ghana. PMID: 28520715
  9. CD16 and CD35 are important for neutrophil internalization of M. tuberculosis, whereas HIV-1 infection adversely affects opsonophagocytosis. PMID: 27258232
  10. This study demonstrates an up-regulation of complement regulatory proteins, CD35 and CD55 in HIV associated pre-eclamptic compared to normotensive pregnancy. PMID: 27521598
  11. Although B lymphocytes of active systemic lupus erythematosus (SLE) patients express lower level of CR1, the inhibitory capacity of this complement receptor is still maintained and its ligand-induced clustering results in significant inhibition of the main B cell functions, similar to that found in the case of healthy individuals. PMID: 27981054
  12. CyaA binding did not trigger downstream signaling of CR3 in human monocytes and CyaA-catalyzed elevation of cAMP effectively blocked CR3 signaling initiated by a natural ligand. PMID: 26650353
  13. the Putative Role of CR1 in Alzheimer's Disease PMID: 26914463
  14. Knops blood group antigen a/b genotype was associated with increased susceptibility to severe malaria and the b/b genotype was associated with reduced risk of severe malaria. PMID: 25916414
  15. The C4d/CR1 ratio is a simple and quickly determinable biomarker that enables the differentiation between infection and flare-up in febrile SLE patients at initial evaluation. PMID: 26273660
  16. This meta-analysis further supports previous findings that CR1 rs6656401 polymorphism contributes to Alzheimer's Disease susceptibility. PMID: 24878768
  17. Complement receptor type 1 (CR1/CD35) expressed on activated human CD4+ T cells contributes to generation of regulatory T cells PMID: 25742728
  18. These results provide a framework for understanding how loss of CR1 expression on podocytes may contribute to complement-mediated damage in the kidney. PMID: 26260209
  19. findings provide evidence that the A carrier (AG/GG) and the A allele of the ECR1 A3650G polymorphism may be correlated to the pathogenesis of NRDS and, hence, might be involved in the susceptibility to NRDS. PMID: 25494101
  21. CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms may not be involved in susceptibility to malaria in Chinese population. PMID: 25683978
  22. In addition to being a risk factor for Alzheimer's disease development, a CR1 SNP appears to be associated with higher rates of medium-term disease progression PMID: 24998857
  23. Data indicate that complement activation promote complement component 3 C3b deposition on native and acetylated LDL and binding to the complement receptor 1 (CR1). PMID: 25349208
  24. A meta-analysis demonstrated significant associations of both the CR1 rs6656401 and CR1 rs3818361 polymorphisms with late-onset Alzheimer's disease susceptibility. PMID: 24996192
  25. CR1 SNPs correlates with specific aspects of cognitive impairment in Alzheimer's disease patients. PMID: 24530172
  26. This study identified nominally significant or suggestive associations between the LOAD-risky CR1 variants and worse Logical Memory immediate recall scores in blacks. PMID: 23643458
  27. Increased CR1 expression was associated with histology classification. PMID: 23464487
  28. CR1 rs7525160 G > C polymorphism was associated with an increased risk of developing non-small cell lung cancer in Chinese population PMID: 24621201
  29. Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria. PMID: 24038027
  30. this is the first study to elucidate the relationship of the L-CR1 transcript with the disease activity of RA patients. PMID: 24433281
  31. Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. PMID: 24214979
  32. Maternal coding variants in complement receptor 1 is associated with spontaneous idiopathic preterm birth. PMID: 23591632
  33. two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study PMID: 22244847
  34. It did not explain (part of) the association of genome wide association top single-nucleotide polymorphisms rs3818361/rs6656401, nor of the CR1copy number variation, with Alzheimer disease in our cohort PMID: 23582656
  35. ATP release following CR1 ligation increases the mobility of the lipid fraction of RBC membranes, which in turn facilitates CR1 clustering, and thereby enhances the binding avidity of complement-opsonized particles to the RBC CR1. PMID: 24022490
  36. Data show that increased CD35, CD46, CD55 and CD59 on neutrophils and monocytes present potent markers of bacterial infection and viral infection. PMID: 23376460
  37. The CD35 antigen bounds gp350/220 and became latently infected when the fusion receptor HLA II was coexpressed. PMID: 23416052
  38. Genome-wide association studies found 3 new susceptibility loci for Alzheimer disease(AD): complement receptor 1,clusterin,and the phosphatidylinositol-binding clathrin assembly protein. These SNPS are not associated with AD in a Polish population. PMID: 23650005
  39. Our findings suggest complex mechanisms underlying the interaction of CR1, APOE, and brain amyloid pathways in Alzheimer disease PMID: 23022416
  40. Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients. PMID: 22962438
  41. We identified rare small events overlapping CR1 and BIN1 in Alzheimer's disease and normal controls with opposite copy number variation dosage. PMID: 23202439
  42. Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization. PMID: 23440418
  43. There are fewer mono- or dinucleated, but dramatically more numbers of tri- or polynucleated megakaryocytes in the bone marrow of transgenic Crry mice. PMID: 23390291
  44. Common CR1 variants significantly protect against severe malaria in an endemic area. PMID: 23152904
  45. In conclusion, despite there are some limitations, this meta-analysis indicates that the A allele of the CR1 SNP rs6656401 is significantly associated with LOAD susceptibility in Chinese Han populations. PMID: 22960360
  46. The clustering phenomenon of CR1 in erythrocytes is identified in electron microscopy. PMID: 22374251
  47. our results support that the CR1-S isoform explains the GWAS signals and open a novel prospect for the investigation of CR1-related disease mechanisms. PMID: 22819390
  48. Simultaneous quantitative analysis of CD64 and CD35 expression on neutrophils might be useful to distinguish between bacterial and viral infections in rheumatoid arthritis patients. PMID: 22237765
  49. CR1 (CD35) and CR3 (CD11b/CD18) act in concert for phagocytosis of opsonized Francisella tularensis by human neutrophils. PMID: 22888138
  50. CLU and CR1 were associated with more rapid cognitive decline. PICALM was associated with an earlier age at midpoint of cognitive decline. PMID: 22952074
  51. In conclusion, we confirmed association of CLU, CR1, and PICALM genes with the disease status in our cohort through identification of a number of disease-specific variants PMID: 22402018
  52. HL and LL genotypes of CR1 gene may be associated with idiopathic pulmonary fibrosis. PMID: 22333472
  53. identify a CR1 coding variant that influences episodic memory decline; it is a variant known to alter the conformation of CR1 PMID: 22343410
  54. The SNP genotype pattern at the CR1 gene is associated with episodic memory. PMID: 22539578
  55. The results of this study supported a role for CR1 in the pathogenesis of Alzheimer disease. PMID: 21403675
  56. CR1 variants are not associated with sporadic Alzheimer's disease in a population of Chinese patients. PMID: 21358043
  57. variants in BIN1, CLU, CR1 or PICALM are associated with changes in the CSF levels of biomarkers PMID: 21347408
  58. The CR1 variant rs6656401 influences risk and recurrence of cerebral amyloid angiopathy-intracerebral hemorrhage, as well as the severity of vascular amyloid deposition PMID: 22262751
  59. findings showed evidence of CR1, CLU, and PICALM and late-onset Alzheimer's disease (LOAD) susceptibility in an independent southern Chinese population PMID: 22015308
  60. these data support the role of malaria leading to positive selection of this CR1 haplotype in Sardinia. PMID: 21593778
  61. CR1 risk allele (A) carriers showed smaller local gray matter volume in the entorhinal cortex PMID: 21726919
  62. significance of leukocyte CR1 as a prognostic marker for SLE PMID: 21659422
  63. relationship of Parkinson's disease with SNPs of CLU, CR1 and PICALM PMID: 21912625
  64. findings suggest individuals with low CR1 expression are ill-equipped to clear immune complexes and prevent immune complexe-mediated stimulation of macrophages PMID: 21985366
  65. This study demonistrated that the complement receptor 1 gene may contribute to Alzheimer's disease risk, although its effect size could be smaller than previously estimated. PMID: 21784344
  66. Human soluble form complement receptor 1 (sCR1) and heparin were co-immobilized onto the surfaces of islet cells. PMID: 21663961
  67. Data show no correlation between degree of expression of RBC surface receptors CR1, CD55 and CD59 with haemoglobin level, but CD55 expression was less in malaria cases than in healthy controls. PMID: 21727667
  68. complement-dependent binding of Gram-negative bacteria to erythrocyte CR1 decreases phagocytosis and oxidative burst by leukocytes in human whole blood PMID: 21839519
  69. Genetic variation in CR1 influences interindividual variation in erythrocyte sedimentation rate, highlighting an association between the innate immunity pathway and erythrocyte interactions. PMID: 21700265
  70. Data show that soluble complement receptor 1 on islet cells inhibits complement activation and protects islets against attack by xenoreactive antibodies and complement. PMID: 21459435
  71. Plasmodium falciparum field isolates use CR1 as a receptor for invasion of erythrocytes. PMID: 21251929
  72. We therefore highlight 1 functional consequence of the CR1 susceptibility allele and generalize the role of this locus to cognitive aging in the general population. PMID: 21391232
  73. In this review, CR1 is a major Alzheimer disease susceptibility gene that is implicated directly in the herpes simplex virus life cycle and plays a general role in pathogen defense. PMID: 20674675
  74. This study provides compelling independent evidence that genetic variants in CLU, CR1, and PICALM are genetically associated with risk for AD. PMID: 21300948
  75. Results suggest strong association between the CR1 C5507G gene polymorphism and cardiovascular disease in end-stage renal disease patients. PMID: 20538029
  76. This study confirmed in a completely independent data set that CR1, CLU, and PICALM are AD susceptibility loci in European ancestry populations. PMID: 20697030
  77. These results demonstrate that CR1 is an erythrocyte receptor used by the parasite ligand PfRh4 for P. falciparum invasion. PMID: 20855594
  78. Human CR1 transgenic mice lacking plasma, platelet, and podocyte factor H spontaneously develop proliferative glomerulonephritis, which is accelerated in a chronic serum sickness model. PMID: 20702729
  79. This study provides the evidence that variations in the CR1 gene play an important role in the pathogenesis of sporadic late-onset Alzheimer's disease in the Han Chinese population. PMID: 20558149
  80. Data confirmed genetic associations for Alzheimer's disease with APOE, CLU, PICALM and CR1 SNPs. PMID: 20534741
  81. Polymorphisms of CR1 are not associated with significant protection against P. falciparum blood-stage infection or uncomplicated malaria in school-aged children. PMID: 20889874
  82. The level of CD35 was significantly elevated in patients with severe Mycoplasma infection. PMID: 20646210
  83. The physiology and molecular basis of the Knops blood group antigen CR1 is discussed. Review. PMID: 20795311
  84. These results show near-perfect replication and provide the first additional evidence that CR1 is associated with the risk of late onset alzheimer disease. PMID: 20554627
  85. In this review of CR1, the receptor for C3b/C4b complement peptides has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of autoimmune and inflammatory diseases. PMID: 19874218
  86. process of rosetting in the Indian context could be occurring independently of the effect of Knops polymorphism and in part could be controlled by other polymorphisms of the CR1 gene. PMID: 19959855
  87. CR1 multimeric ligand inhibits the proliferation of tonsil B cells activated with a suboptimal dose of anti-IgM F(ab')2. PMID: 11884446
  88. The structure of the principal C3b/C4b binding site (residues 901-1095) of CR1 is reported, revealing three complement control protein modules (modules 15-17) in an extended head-to-tail arrangement with flexibility at the 16-17 junction PMID: 11955431
  89. relative contributions of CR1 and CR2 to the deposition of C3 fragments and MAC on B lymphocytes under circumstances where all complement pathways are operational PMID: 11981823
  90. The presence of CR1 (CD35) and CR4 (CD1c/CD18) on HUVEC indicates that endothelial cells (EC) have the potential to bind C3b and iC3b, respectively, which both mediate biological effects in the course of complement activation. PMID: 12083416
  91. CR1 gene as a possible susceptibility factor in sarcoidosis. PMID: 12091241
  92. No relationship has been found between erythrocyte CR1 expression level and genotype for the HindIII restriction fragment length polymorphism when correlated with malaria susceptibility in West Africa. PMID: 12486610
  93. data suggest that erythrocyte cell surface domains rich in CR1, but not in DAF, are specifically lost in factor I deficiency PMID: 12490287
  94. Complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) cooperate in the binding of hydrolyzed complement factor 3 (C3i) to human B lymphocytes. PMID: 14635039
  95. CR1 deficiency occurs in up to 80% of healthy individuals from the malaria-endemic regions of Papua New Guinea. This CR1 deficiency is associated with polymorphisms in the CR1 gene and, with alpha-thalassemia, a common genetic disorder in Melanesia. PMID: 14694201
  96. Reduced CR1 synthesis causes the low cell-surface CR1 expression in SLE. Increased proteolytic cleavage of leukocyte cell-surface CR1 may occur. Low leukocyte CR1 impairs phagocyte-mediated immune complex clearance & increase complement consumption. PMID: 15163541
  97. Urinary CR1 is a potential marker for glomerular involvement in systemic lupus erythematosus PMID: 15176657
  98. process in which C3b-opsonized substrates, bound to erythrocyte CR1 by immune adherence, are transferred to acceptor phagocytes PMID: 15388259
  99. The changes in CR1 quantitative expression and adhering activity are consanguineously related to the development and metastasis in gallbladder carcinoma. PMID: 15526369
  100. abnormally high levels of erythrocyte C4d and low levels of erythrocyte CR1 are characteristic of systemic lupus erythematosus PMID: 15529364

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Receptors of complement activation (RCA) family
Tissue Specificity Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
Database Links

HGNC: 2334

OMIM: 120620

KEGG: hsa:1378

STRING: 9606.ENSP00000356016

UniGene: Hs.334019


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