Recombinant Mouse Receptor tyrosine-protein kinase erbB-2 (Erbb2), partial

1. High HER2 expression is associated with metastasis in breast Cancer. PMID: 29187405
2. Study shows that within endoplasmic reticulum-related subsurface cistern, sigma-1 receptors, Kv2.1 and neuregulin-1 are clustered in highly specific, non-overlapping, microdomains, whereas ErbB2 and ErbB4 are present in the adjacent presynaptic compartment. This organization may define highly ordered and spatially restricted sites for different signal-transduction pathways. PMID: 28065942
3. ErbB2 interacts with Nrp1 to form a Sema3d co-receptor expressed by developing coronary endothelium and required for proper connections of the forming coronary veins to the right atrium. PMID: 27356767
4. The objective of this study was to determine if loss of Stard13 plays a role in mammary tumor progression using transgenic mice expressing the activated ErbB-2 (Neu) oncogene and Cre recombinase (NIC) in mammary epithelium under transcriptional control of the murine mammary tumor virus (MMTV) promoter (MMTV-NIC). PMID: 29218825
5. Over-expression of HER2 remarkably enhanced the proliferation, invasion and migration of B16 cells. PMID: 28871948
6. Results indicate the importance of the LDL receptor (LDLR) in the growth of triple-negative and HER2-overexpressing breast cancers in the setting of elevated circulating LDL cholesterol (LDL-C). PMID: 28759039
7. caErbB2 markedly enhances regeneration of damaged dorsal roots, while evoking little change in intact roots PMID: 28982707
8. immunocompetent mouse models of HER2/ErbB2-driven breast cancer, CD73 expression by tumor cells and host cells significantly suppressed immune-mediated responses mediated by anti-ErbB2 mAb. PMID: 28855210
9. We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2-positive breast cancer escapes p110alpha inhibition. PMID: 28783168
10. sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of hypertrophic obstructive cardiomyopathy PMID: 27538857
11. investigations revealed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late endosome for degradation. PMID: 28067668
12. ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators. PMID: 27390088
13. Despite previous evidence suggesting that ErbB receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS pathway in mouse breast cancer model. PMID: 27765041
14. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis PMID: 26423570
15. Study showed that suppression of STAT3, STAT5, and STAT6 and overexpression of the proapoptotic factor STAT1, which provides p53-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor overexpression promotes neuronal survival through activation of STAT-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 PMID: 27417725
16. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity PMID: 26692570
17. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha-VEGF signaling axis in mediating HER2-induced tumor angiogenesis. PMID: 26625311
18. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer. PMID: 26791520
19. ErbB2 receptor tyrosine kinase in AECs was activated by annexin V, and blockade reduced the fibrotic potential of annexin V-treated AEC-conditioned medium. PMID: 26160872
20. Disabling of the erbB pathway followed by IFNg modifies phenotype and enhances genotoxic eradication of breast tumors. PMID: 26365188
21. Ptk6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse. PMID: 26247733
22. PTPN12-deficient, ErbB2-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties. PMID: 26391955
23. ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. PMID: 26254336
24. These results indicate that OCAM exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB signalling PMID: 25875008
25. the Krt6a-positive subset of mammary epithelial cells can be induced to form cancer by ErbB2. PMID: 25635772
26. These results suggested that DS/Cu treatment may be a promising therapy for the prevention of erbB2-positive breast cancer PMID: 25738885
27. loss of Postn in an ErbB2/Neu/HER2 overexpression model results in apocrine-like tumors that activate an AR-dependent pathway. PMID: 25592291
28. Inhibition of Erbb2 suppressed the increase in metalloproteinase ADAM12 expression in skin tumors. PMID: 24798404
29. Data show that Muc4 is upregulated and interacts with erbB2 in gallbladders from BK5.erbB2 mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 signaling. PMID: 25174601
30. ERBB2 is both necessary for cardiac myocyte proliferation and sufficient to reactivate postnatal CM proliferative and regenerative potentials. PMID: 25848746
31. These findings suggest cooperative roles for bile acid and erbB2 activation in epithelial cell proliferation; bile acid appears to accelerate erbB2-induced pro-tumorigenic activities in the biliary tract and skin. PMID: 24839254
32. A novel function of Erbb2 during atrial conduction system development. PMID: 25269082
33. Data demonstrate that the E2F transcription factors are integral to HER2+ tumor development and progression. PMID: 24362522
34. Results support that hyperglycemia may impair NRG1/Erb B2 signaling by disrupting the balance between NRG1 isoforms, decreasing the expression of erbin and correspondingly activating the MAPK pathway PMID: 24252174
35. ERBB2-positive breast cancers are partially autophagy-deficient even in a wild-type BECN1 background PMID: 24492513
36. The nuclear ErbB-2 and Stat3 are key players in progestin-induced p21(CIP1) regulation. PMID: 23178160
37. In the HER2 mouse model, ErbB2 inhibition delays cancer progression, which is associated with HSF1 inactivation and destabilization of HSP90 targets. PMID: 24384723
38. Wnt pathway-active cell subset in the normal mammary epithelium does not evolve into tumors following ErbB2 activation PMID: 24265712
39. These results suggest that H. pylori CagA may induce overexpression of the HER-2 protein by increasing HER-2 DNA and mRNA copy number PMID: 24879917
40. CREB plays an important role in the HER-2/neu-mediated transformation by altering in vitro and in vivo growth characteristics. PMID: 24025972
41. A novel time-window is identified for embryonic stem cell cardiomyogenesis via Erbb2. PMID: 24364879
42. Her-2 and beta-catenin appeared co-localized at the cell surface during tumor development and progression. PMID: 23397229
43. Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis. PMID: 23318421
44. Myocilin binds to ErbB2/ErbB3, activates these receptors, and affects the downstream PI3K-AKT signaling pathway PMID: 23897819
45. PIK3CA(H1047R) accelerates HER2-mediated breast epithelial transformation and metastatic progression, alters the intrinsic phenotype of HER2-overexpressing cancers, and generates resistance to approved combinations of anti-HER2 therapies PMID: 23940356
46. interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells. PMID: 23447672
47. the acquired substrate preference for GAB1 is critical for the ERBB2 mutant-induced oncogenesis. PMID: 23612964
48. HIF is a major downstream regulator of ERBB2 that protects cells from anoikis and metabolic stress caused by decreased matrix adhesion. PMID: 23585570
49. HTT protein accelerates breast tumour development and metastasis through ErbB2 signalling. PMID: 23300147
50. DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis. PMID: 23592719

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KEGG: mmu:13866

STRING: 10090.ENSMUSP00000053897

UniGene: Mm.290822