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| Code | CSB-PA001291 |
| Size | US$167 |
| Uniprot No. | P35222 |
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| Immunogen | Synthesized peptide derived from Human Catenin-β around the non-phosphorylation site of S37. |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Tested Applications | WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Alias | CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol ELISA Protocol |
| Target Names | CTNNB1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin |
| Involvement in disease | Colorectal cancer (CRC); Pilomatrixoma (PTR); Medulloblastoma (MDB); Ovarian cancer (OC); Mesothelioma, malignant (MESOM); Mental retardation, autosomal dominant 19 (MRD19); Vitreoretinopathy, exudative 7 (EVR7) |
| Subcellular Location | Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, Cell junction, adherens junction, Cell junction, Cell membrane, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle pole, Cell junction, synapse |
| Protein Families | Beta-catenin family |
| Tissue Specificity | Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (Pub |
| Database Links |
HGNC: 2514 OMIM: 114500 KEGG: hsa:1499 STRING: 9606.ENSP00000344456 UniGene: Hs.476018 |
| Pathway |
Hippo signaling pathway
Melanogenesis Wnt signaling pathway Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Leukocyte transendothelial migration Rap1 signaling pathway |
CTNNB1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA00174A0Rb | CTNNB1 Antibody | Human | ELISA, WB, IHC, IF, IP |
| CSB-PA00174B0Rb | CTNNB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA00174C0Rb | CTNNB1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA00174D0Rb | CTNNB1 Antibody, Biotin conjugated | Human | ELISA |
CTNNB1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA006169GA01HU | CTNNB1 Antibody | Human,Mouse,Rat,Zebrafish | ELISA,WB,IHC |
| CSB-RA006169A33phHU | Phospho-CTNNB1 (S33/S37) Antibody | Human | ELISA, IF |
| CSB-PA271248 | Phospho-CTNNB1 (Thr41/Ser45) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA978882 | Phospho-CTNNB1 (Ser33) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA596316 | Phospho-CTNNB1 (Ser37) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA084843 | CTNNB1 (Ab-41/45) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA271206 | CTNNB1 (Ab-33) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA118626 | CTNNB1 (Ab-37) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA134662 | CTNNB1 (Ab-654) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA931695 | CTNNB1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA029484 | Phospho-CTNNB1 (Tyr489) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA915531 | CTNNB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA064130 | Phospho-CTNNB1 (Tyr670) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-MA000223 | CTNNB1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000489 | Phospho-CTNNB1 (S37) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA000490 | Phospho-CTNNB1 (T41/S45) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA000756 | Phospho-CTNNB1 (S552) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA001269 | CTNNB1 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA001271 | CTNNB1 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA001272 | CTNNB1 Antibody | Human,Mouse,Rat,Monkey | WB,IHC,IF,ELISA |
| CSB-PA001283 | CTNNB1 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA001292 | CTNNB1 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA007419 | Phospho-CTNNB1 (S33) Antibody | Human,Mouse,Rat | IHC,IF,ELISA |
| CSB-PA007420 | Phospho-CTNNB1 (Y654) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA007422 | Phospho-CTNNB1 (Y489) Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ELISA |
| CSB-PA007423 | CTNNB1 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA080139 | CTNNB1 Antibody | Mouse,Rat | WB |
| CSB-MA080197 | CTNNB1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CTNNB1 Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA150703 | Phospho-CTNNB1 (Tyr333) Antibody | Human | ELISA,WB,IHC |
CTNNB1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP006169HU | Recombinant Human Catenin beta-1(CTNNB1) | Yeast |
| CSB-EP006169HU | Recombinant Human Catenin beta-1(CTNNB1) | E.coli |
| CSB-BP006169HU CSB-MP006169HU |
Recombinant Human Catenin beta-1(CTNNB1) | Baculovirus Mammalian cell |
CTNNB1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08963h | Human Catenin beta-1 (CTNNB1/CTNNB/OK/SW-cl.35/PRO2286) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 3.9 pg/mL |
2-hydroxyisobutyryl-HIST1H1C (K158) Antibody
Applications: ELISA, WB, ICC, ChIP
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H2BC (K12) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K18) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K23) Antibody
Applications: ELISA, WB, IF, ChIP
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K5) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
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