CTNNB1 Antibody

^Datasheet

Specification
Target

Code	CSB-PA001291
Size	US$167
Uniprot No.	P35222
Image	Western Blot analysis of HT29 cells using Catenin-β Polyclonal Antibody Western Blot analysis of MCF7 cells using Catenin-β Polyclonal Antibody
Immunogen	Synthesized peptide derived from Human Catenin-β around the non-phosphorylation site of S37.
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat
Tested Applications	WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000
Form	Liquid
Conjugate	Non-conjugated
Storage Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype	IgG
Alias	CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin
Immunogen Species	Homo sapiens (Human)
Protocols	Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol ELISA Protocol
Target Names	CTNNB1
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function	Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin
Involvement in disease	Colorectal cancer (CRC); Pilomatrixoma (PTR); Medulloblastoma (MDB); Ovarian cancer (OC); Mesothelioma, malignant (MESOM); Mental retardation, autosomal dominant 19 (MRD19); Vitreoretinopathy, exudative 7 (EVR7)
Subcellular Location	Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, Cell junction, adherens junction, Cell junction, Cell membrane, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle pole, Cell junction, synapse
Protein Families	Beta-catenin family
Tissue Specificity	Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (Pub
Database Links	HGNC: 2514 OMIM: 114500 KEGG: hsa:1499 STRING: 9606.ENSP00000344456 UniGene: Hs.476018
Pathway	Hippo signaling pathway Melanogenesis Wnt signaling pathway Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Leukocyte transendothelial migration Rap1 signaling pathway

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CTNNB1 Antibodies for Human

Code	Product Name	Species Reactivity	Application
CSB-PA00174A0Rb	CTNNB1 Antibody	Human	ELISA, WB, IHC, IF, IP
CSB-PA00174B0Rb	CTNNB1 Antibody, HRP conjugated	Human	ELISA
CSB-PA00174C0Rb	CTNNB1 Antibody, FITC conjugated	Human	ELISA
CSB-PA00174D0Rb	CTNNB1 Antibody, Biotin conjugated	Human	ELISA

CTNNB1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA006169GA01HU	CTNNB1 Antibody	Human,Mouse,Rat,Zebrafish	ELISA,WB,IHC
CSB-RA006169A33phHU	Phospho-CTNNB1 (S33/S37) Antibody	Human	ELISA, IF
CSB-PA271248	Phospho-CTNNB1 (Thr41/Ser45) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA978882	Phospho-CTNNB1 (Ser33) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA596316	Phospho-CTNNB1 (Ser37) Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA084843	CTNNB1 (Ab-41/45) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA271206	CTNNB1 (Ab-33) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA118626	CTNNB1 (Ab-37) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA134662	CTNNB1 (Ab-654) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA931695	CTNNB1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA029484	Phospho-CTNNB1 (Tyr489) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA915531	CTNNB1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA064130	Phospho-CTNNB1 (Tyr670) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-MA000223	CTNNB1 Monoclonal Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA000489	Phospho-CTNNB1 (S37) Antibody	Human,Mouse,Rat	WB,IHC,IF,ELISA
CSB-PA000490	Phospho-CTNNB1 (T41/S45) Antibody	Human,Mouse,Rat	WB,ELISA
CSB-PA000756	Phospho-CTNNB1 (S552) Antibody	Human,Mouse,Rat	WB,ELISA
CSB-PA001269	CTNNB1 Antibody	Human,Mouse,Rat	WB,IHC,IF,ELISA
CSB-PA001271	CTNNB1 Antibody	Human,Mouse,Rat	WB,ELISA
CSB-PA001272	CTNNB1 Antibody	Human,Mouse,Rat,Monkey	WB,IHC,IF,ELISA
CSB-PA001283	CTNNB1 Antibody	Human,Mouse,Rat	WB,ELISA
CSB-PA001292	CTNNB1 Antibody	Human,Mouse,Rat	WB,IHC,IF,ELISA
CSB-PA007419	Phospho-CTNNB1 (S33) Antibody	Human,Mouse,Rat	IHC,IF,ELISA
CSB-PA007420	Phospho-CTNNB1 (Y654) Antibody	Human,Mouse,Rat	WB,IHC,ELISA
CSB-PA007422	Phospho-CTNNB1 (Y489) Antibody	Human,Mouse,Rat,Monkey	WB,IHC,ELISA
CSB-PA007423	CTNNB1 Antibody	Human,Mouse,Rat	WB,ELISA
CSB-PA080139	CTNNB1 Antibody	Mouse,Rat	WB
CSB-MA080197	CTNNB1 Monoclonal Antibody	Human,Mouse,Rat	ELISA,WB,IHC

CTNNB1 Antibodies for

Code	Product Name	Species Reactivity	Application
CSB-PA150703	Phospho-CTNNB1 (Tyr333) Antibody	Human	ELISA,WB,IHC

CTNNB1 Proteins

CTNNB1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP006169HU	Recombinant Human Catenin beta-1(CTNNB1)	Yeast
CSB-EP006169HU	Recombinant Human Catenin beta-1(CTNNB1)	E.coli
CSB-BP006169HU CSB-MP006169HU	Recombinant Human Catenin beta-1(CTNNB1)	Baculovirus Mammalian cell

CTNNB1 ELISA Kit

CTNNB1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E08963h	Human Catenin beta-1 (CTNNB1/CTNNB/OK/SW-cl.35/PRO2286) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	3.9 pg/mL

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