Recombinant Mouse Carbonic anhydrase 2 (Ca2)

1. It was concluded that both MCT1 and CAII are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1(+/-) mice remain unexplained. PMID: 28254758
2. two CA isoforms, CAII and CAIV, are distributed along the epididymal epithelium and appear with the onset of puberty PMID: 26487715
3. The Na(+)-Cl(-) cotransporter NCC /Carbonic anhydrase II double Knockout mice displayed significant downregulation of pendrin, along with polyuria and salt wasting. PMID: 24429824
4. CA2 expression is strongly regulated by intracellular pH and by cAMP, suggesting a role for soluble adenylyl cyclase PMID: 24361611
5. sclerostin upregulated osteocyte expression of carbonic anhydrase 2. PMID: 23737439
6. Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland. PMID: 20820888
7. Suggest that during amelogenesis CAII controls the differentiation of ameloblasts. Regulation of intracellular pH, followed by activation of the JNK signaling pathway, may be responsible for the effects of CAII on ameloblasts. PMID: 20533306
8. Both kNBC1-Asp(986) and kNBC1-Asp(988), but not kNBC1-Asp(989), are required for the phosphorylation-induced shift in stoichiometry. A homologous motif (D887ADD) in the carboxy-terminus of the anion exchanger AE1 binds to carbonic anhydrase II. PMID: 12411514
9. carbonic anhydrases have a functional role specifically in endometrial gland development during postnatal mouse uterine morphogenesis. PMID: 15788756
10. Results show that the stimulatory effect of the duodenal secretagogue prostaglandin E2 completely depends on carbonic anhydrase II. PMID: 16217040
11. Altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia. PMID: 16247769
12. These results suggest that the loss of function of cytosolic CA II in the stomach of Car2-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium. PMID: 16396925
13. Expression in pancreas is restricted to cells within ductal structures and glucagon-positive cells with no colocalization with any insulin-positive cells at any time. PMID: 16586439
14. In conclusion, skeletal muscle from mice deficient in CA II exhibits altered handling of acid-base challenges and shows normal contractile behavior at normal intracellular pH. PMID: 16601982
15. identification of serum CA-II as an acute-phase protein; first report that CA-II circulates in the serum following inflammation PMID: 17298961
16. Immunoblot analyses showed that the levels of carbonic anhydrase II are increased in the brain of Ts65Dn mice, a mouse model for Down syndrome. PMID: 18083150
17. The metaphyseal widening and changes in the trabecular bone are consistent with osteopetrosis, making the CAII-deficient mouse a valuable model of human disease. PMID: 18175028
18. CAII deficiency results in a significant decrease in the gene and protein expression of bicarbonate transport proteins from Slc26 gene family - Slc26a4 (pendrin) and Slc26a7. PMID: 18209476
19. Carbonic anhydrase II is important for duodenocyte acidification by low luminal pH and for eliciting the acid-mediated HCO(3)(-) secretory response. PMID: 19622732

Show More

Hide All

KEGG: mmu:12349

STRING: 10090.ENSMUSP00000029078

UniGene: Mm.1186