Code | CSB-RA024077A55phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IF | 1:20-1:200 |
The phospho-TP53 (T55) monoclonal antibody's DNA sequence was inserted into the plasmid, which was subsequently transfected into the cell line for expression. The phospho-TP53 (T55) recombinant monoclonal antibody was produced after purification using affinity chromatography. This rabbit IgG phospho-TP53 (T55) recombinant antibody has been evaluated in scientific applications such as ELISA, WB, and IF. The T55 phospho-specific antibody exclusively reacts with phosphorylated human TP53 at Thr 55.
The tumor suppressor P53 is a transcriptional factor involved in the modulation of cell growth, cell cycle, apoptosis, and senescence. TP53 is tightly regulated by posttranslational modifications. Phosphorylation of TP53 plays an important role in the cellular response to various stresses. Phosphorylation of multiple sites in the inherently disordered N-terminal transactivation domain activates TP53 after DNA damage. During various stages of the cellular DNA damage response, the phosphorylation status of Thr55 regulates both the activation and termination of p53-mediated transcriptional programs.
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