AFG2A

AFG2A encodes the ATPase family gene 2 - like protein A. Commonly, it is also known as a key player in protein quality control within cells. This protein functions through its ATP - dependent activity, which allows it to unfold and translocate misfolded proteins for degradation. It participates in the ubiquitin - proteasome pathway, ensuring cellular homeostasis.
Dysregulation of AFG2A has been linked to neurodegenerative diseases, as protein aggregation is a hallmark of these conditions. In drug development, researchers are exploring small molecules that can modulate the activity of AFG2A, aiming to correct protein - handling defects and potentially treat related disorders. Ongoing studies are crucial for translating these findings into effective therapies.