ASB3

ASB3, a protein that encompasses anchor repeat and SOCS elements, functions as an E3 ubiquitin ligase, orchestrating the degradation of intracellular proteins through ubiquitination. Richly expressed in tissues like the liver, brain, and reproductive system, ASB3's primary mechanism involves interacting with target proteins, particularly in the regulation of intracellular signal transduction via the ubiquitin-proteasome pathway. It can facilitate the ubiquitination and degradation of DR5, impacting cell sensitivity to TRAIL and playing a significant role in the development of hepatocellular carcinoma (HCC). ASB3's high expression levels in various cancers, including liver cancer, link it to poorer prognoses. Beyond its significant role in tumor biology, ASB3 may also serve as a target for innovative anti-liver cancer and antiviral therapies, offering new avenues and strategies for treating related diseases.