ASPM

ASPM, short for abnormal spindle-like microcephaly associated, is a protein-encoding gene. The full - length protein is known as abnormal spindle microcephaly - associated protein. A common alias is ASP. This protein is crucial in regulating spindle orientation during mitosis, a key process for cell division. It participates in the Wnt signaling pathway, which is essential for cell proliferation and differentiation.
Mutations in ASPM are strongly linked to primary microcephaly, a disorder characterized by a significantly smaller head size and intellectual disability. In terms of drug development, currently, there are no specific drugs targeting ASPM, but research focuses on understanding its mechanisms to find potential therapeutic targets for related genetic diseases.