ATP11B

ATP11B, alias ATPase phospholipid transporting 11B (putative), KIAA0956, DKFZP434N1615 and so on. It is a transmembrane ATPase belonging to the ATPase family type VI, type 11B, which is encoded by its own gene in human cells.The mechanism of action of ATP11B mainly involves the provision of energy through ATP hydrolysis to facilitate the process of phospholipid transport across cell membranes, and it is thought to play a role in intracellular signaling, metabolic regulation, cell adhesion, and intracellular transport.

The significance of ATP11B in the biological significance is mainly reflected in its role in the regulation of cell membrane phospholipid transport. It is involved in important processes that maintain cell membrane integrity and function, and may play a role in cell survival, especially against certain anticancer drugs. In addition, the expression level of ATP11B is increased in some cancers, suggesting that it may be associated with drug resistance in tumor cells. Therefore, ATP11B is considered a potential target in drug development and disease treatment .

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Recombinant Rabbit Probable phospholipid-transporting ATPase IF (ATP11B), partial