BAZ1B

The protein encoded by BAZ1B, officially named bromodomain adjacent to zinc finger domain 1B, is commonly referred to as WSTF (Williams syndrome transcription factor). It functions as a chromatin remodeler, regulating gene expression through ATP-dependent chromatin remodeling and histone modification, particularly interacting with acetylated histones via its bromodomain.
BAZ1B participates in several key signaling pathways, including the Wnt/β-catenin and PI3K/Akt pathways, governing cell cycle progression and DNA repair. Mutations in BAZ1B are linked to Williams-Beuren syndrome, characterized by cognitive deficits and cardiovascular abnormalities. Its role in chromatin regulation makes it a potential target for epigenetic therapies, though specific drug development remains in preclinical stages focused on bromodomain inhibition.