BTG3

BTG3, a member of the BTG/Tob family and located on chromosome 21, plays a multifaceted role in cellular regulation. It interacts with transcription factors within the nucleus to curb cell cycle progression and proliferation by binding to E2F1 and Smad3, among others. Additionally, in the cytoplasm, BTG3 suppresses signaling pathways involving src, Akt, and Ras/MAPK. Frequently down-regulated in tumors, BTG3's expression levels are significantly associated with tumor invasion and patient prognosis, positioning it as a potential tumor suppressor gene with substantial implications for cancer research and treatment.