CACNA1I

CACNA1I encodes the calcium voltage-gated channel subunit alpha1 I, also known as Cav3.3. It is a key component of T-type calcium channels. These channels mediate low - threshold calcium currents, which play a crucial role in the regulation of neuronal excitability, pace - making activity, and synaptic plasticity. They are involved in the GABAergic signaling pathway.
Dysfunctions of CACNA1I have been associated with neurological diseases like absence epilepsy. In drug development, efforts are underway to design selective blockers of Cav3.3 channels. These potential drugs could offer new therapeutic options for patients with related calcium - channel - associated disorders.