CALHM2

CALHM2, also known as calcium homeostasis modulator 2, is a voltage-gated ATP release channel that plays a crucial role in regulating calcium levels and ATP release in the central nervous system. It functions as a nonselective ion channel, acting as a major ATP release channel and influencing gustatory signaling and neuronal toxicity. CALHM2 is involved in calcium homeostasis and has been linked to neurological disorders such as Alzheimer's disease. Its dysfunction may contribute to neuroinflammation and cognitive impairments.
Recent research has identified CALHM2 as a potential therapeutic target for neurological disorders. Studies have shown that CALHM2 knockout can reduce amyloid beta deposition, neuroinflammation, and cognitive impairments in Alzheimer's disease models. The protein's role in calcium influx and inflammatory activation in microglia suggests a potential therapeutic approach for neuroinflammation-related diseases. Further investigation into CALHM2's interaction with other proteins and signaling pathways could lead to the development of novel treatments for neurological disorders.