CCT2

CCT2 encodes chaperonin containing TCP1 subunit 2, a core component of the CCT complex (TRiC). This ATP-dependent molecular chaperone facilitates folding of essential proteins like actin and tubulin, preventing misfolding and aggregation to maintain cellular protein homeostasis—critical for cytoskeleton assembly and cell proliferation.
Dysregulation of CCT2 is linked to lung, breast, and colorectal cancers, where overexpression correlates with tumor growth and poor prognosis. Preclinical studies explore small-molecule inhibitors targeting the CCT complex’s chaperone activity as potential anti-tumor agents, though no candidates have entered clinical trials to date.