CCT2

CCT2, the TCP1 subunit 2 of the chaperone protein, is also known as CCTB, 99D8.1, PRO1633, CCT-beta, HEL-S-100n, and TCP-1-beta. CCT2 is encoded by the human CCT2 gene, which is located on chromosome 12 in the q15 region.
CCT2 is a member of the molecular chaperone TCP1 complex, also known as the member of the TCP1 cyclic complex. The CCT complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and fold in an ATP-dependent manner.CCT2 is involved in the folding of a variety of proteins, including actin and microtubule proteins. As a molecular chaperone, CCT2 is essential for maintaining the dynamic homeostasis of intracellular proteins, and its altered or absent function has been closely associated with cancer and neurodegenerative diseases, among others.
CCT2 has also been identified as a novel aggregate autophagy receptor that promotes autophagic clearance of toxic protein aggregates associated with neurodegenerative diseases, and plays a role in the clearance of solid protein aggregates in particular.

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Recombinant Human Cyclin-T2 (CCNT2)