CLIC5

CLIC5, chloride intracellular channel protein 5, also known as MST130, DFNB102, DFNB103, and MSTP130. CLIC5 is a single transmembrane protein belonging to the CLIC family of chloride channels containing a GSTC-terminal structural domain. CLIC5 is capable of inserting itself into membranes and forming a selective ion channel regulated by actin, and is probably responsible for the transport of chloride ions and is involved in the regulation of trans-epithelial ion uptake and secretion.
CLIC5 is specifically associated with the cytoskeleton of placental microvilli and is essential for the maintenance of normal development or maintenance of glomerular endothelial and podocyte structures. CLIC5 has been associated with actin-based cytoskeletal structures and may play a role in several processes, including hair cell static cilia formation, myofibroblast proliferation, and glomerular podocyte and endothelial cell maintenance. CLIC5 also plays an important role in inner ear function and is associated with hearing and vestibular function, where mutations may result in hearing and vestibular dysfunction.

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Recombinant Human Chloride intracellular channel protein 5 (CLIC5), partial