CTRB1

CTRB1, also known as Chymotrypsinogen B1, is a pancreatic serine protease. This protein is synthesized as an inactive precursor called chymotrypsinogen B1 and is activated in the small intestine. It plays a crucial role in protein digestion by cleaving peptide bonds at specific residues. It is involved in the digestive enzyme activation cascade and is part of the trypsin - chymotrypsin signaling pathway.
Mutations or abnormal expression of CTRB1 have been linked to pancreatic diseases such as pancreatitis. In drug development, efforts are being made to target proteases like CTRB1 to develop therapies for these pancreatic conditions. Some small - molecule inhibitors are under pre - clinical research to modulate its activity for better disease management.