CTSC

Cathepsin C (CTSC), also called dipeptidyl peptidase I (DPP-I), is a lysosomal cysteine protease expressed in innate immune cells like neutrophils and macrophages. It activates proforms of serine proteases (neutrophil elastase, cathepsin G) via dipeptidyl cleavage, critical for host defense and inflammatory responses. This links CTSC to pathways regulating neutrophil degranulation and pathogen clearance.
Biallelic CTSC mutations cause Papillon-Lefèvre syndrome (PLS, palmoplantar keratoderma + early periodontitis) and Haim-Munk syndrome (PLS variant with arachnodactyly). Selective inhibitors like brensocatib (phase3 trials) target CTSC to reduce neutrophil-driven inflammation, evaluated for non-cystic fibrosis bronchiectasis and COPD to mitigate exacerbations.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GR-AMC). The specific activity is >200 pmol/min/μg. The Human CTSC needs to be activated by Human CTSL (CSB-MP006193HU(A4)).

CTSC Antibody (CSB-PA006186LA01HU)

Validated Data

IHC image of CSB-PA006186LA01HU diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The following CTSC reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CTSC Antibodies

CTSC Proteins

CTSC Antibodies

CTSC Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA000029	Cleaved-CTSC (R394) Antibody	Human	WB, ELISA
CSB-PA115010	CTSC Antibody	Human	ELISA,WB,IHC
CSB-PA358929	CTSC Antibody	Human	ELISA,WB,IHC
CSB-PA006186LA01HU	CTSC Antibody	Human	ELISA, IHC
CSB-PA006186LB01HU	CTSC Antibody, HRP conjugated	Human	ELISA
CSB-PA006186LC01HU	CTSC Antibody, FITC conjugated	Human
CSB-PA006186LD01HU	CTSC Antibody, Biotin conjugated	Human	ELISA

CTSC Proteins

CTSC Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP006186RA CSB-EP006186RA CSB-BP006186RA CSB-MP006186RA CSB-EP006186RA-B	Recombinant Rat Dipeptidyl peptidase 1 (Ctsc)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSC Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP006186MO CSB-BP006186MO CSB-MP006186MO CSB-EP006186MO-B	Recombinant Mouse Dipeptidyl peptidase 1 (Ctsc), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSC Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP006186HU CSB-EP006186HU CSB-BP006186HU CSB-EP006186HU-B	Recombinant Human Dipeptidyl peptidase 1 (CTSC), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP006186HU	Recombinant Human Dipeptidyl peptidase 1 (CTSC) (Active)	Mammalian cell

CTSC Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP006186DO CSB-EP006186DO CSB-BP006186DO CSB-MP006186DO CSB-EP006186DO-B	Recombinant Dog Dipeptidyl peptidase 1 (CTSC)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSC Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP671368BO CSB-EP671368BO CSB-BP671368BO CSB-MP671368BO CSB-EP671368BO-B	Recombinant Bovine Dipeptidyl peptidase 1 (CTSC)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSC Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP717180MOV CSB-EP717180MOV CSB-BP717180MOV CSB-MP717180MOV CSB-EP717180MOV-B	Recombinant Macaca fascicularis Dipeptidyl peptidase 1 (CTSC)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSC Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP735773PYX CSB-EP735773PYX CSB-BP735773PYX CSB-MP735773PYX CSB-EP735773PYX-B	Recombinant Pongo abelii Dipeptidyl peptidase 1 (CTSC)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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CTSC

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