DCAF5

DCAF5DDB1- and CUL4-related factor 5 is a protein that interacts with the CRL4-DDB1 E3 ubiquitin ligase complex and has a WD40 β-helix repeat domain. It is involved in the ubiquitination and degradation of proteins. DCAF5 plays a key role in regulating the quality control of the SWI/SNF complex, especially in the absence of SMARCB1, it promotes the degradation of incompletely assembled SWI/SNF complexes and prevents the accumulation of defective complexes that may be toxic to cells. The function of DCAF5 involves the regulation of the SWI/SNF complex and tumor suppression. Its deletion can lead to the re-accumulation of SMARCB1-deficient SWI/SNF complexes, restoring SWI/SNF-mediated gene expression and reversing cancer states. The signaling pathway involved in DCAF5 is mainly the regulation of the SWI/SNF complex, which participates in the tumor suppression signaling pathway by affecting the binding of the SWI/SNF complex on chromatin and regulating gene expression. These findings suggest that DCAF5 is a promising therapeutic target for SMARCB1 mutant cancers and provide a theoretical basis for new treatment strategies for such tumors.