EMC10

EMC10, or endoplasmic reticulum membrane protein complex subunit 10, is a component of the endoplasmic reticulum membrane protein complexes, with isoforms Emce10-1 and Emce10-2 that function in secretory and membrane roles, respectively. Highly conserved EMC10 contributes to a range of biological processes such as glucose metabolism, tumorigenesis, neurological diseases, cardiovascular health, and male fertility. It operates through mechanisms involving the degradation of proteins associated with the endoplasmic reticulum, the connection between the endoplasmic reticulum and mitochondria, and the assembly of multi-transmembrane proteins. EMC10's impact on cellular functions includes regulating cell proliferation, migration, invasion, and it also plays a part in sperm maturation and fertilization, making it a multifaceted player in cellular biology.