ERVK-11

ERVK-11, a member of the human endogenous retrovirus K family, exhibits a typical retroviral structure comprising long terminal repeat sequences (LTRs) and genes encoding viral proteins. While most ERVK-11 sequences have lost functionality due to mutations, some retain transcriptional activity. Functionally, the RNAs and potential proteins encoded by ERVK-11 can indirectly influence cellular processes by interacting with host cell molecules, thereby regulating gene expression and signal transduction. As for signaling pathways, ERVK-11 does not directly participate in known specific signaling cascades, but its molecular products may indirectly affect intracellular signaling cascades. Currently, associations between ERVK-11 and various disease states are being investigated, often through epigenetic mechanisms or the regulation of gene expression. With further research, we will gain a more comprehensive understanding of the role of ERVK-11 in human biology and disease.

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Recombinant Human HERV-K_3q27.3 provirus ancestral Pol protein, partial