GSAP

The protein from the GSAP gene is officially gamma-secretase activating protein, commonly called GSAP or formerly DAP-1. As a regulatory cofactor, it modulates gamma-secretase—an enzyme cleaving amyloid precursor protein (APP)—to boost amyloid-beta (Aβ) production, especially neurotoxic Aβ42 that accumulates in Alzheimer’s disease (AD) brains.
GSAP acts in APP’s amyloidogenic pathway, linking to neuronal survival/synaptic cascades. Dysregulated GSAP worsens Aβ aggregation/plaque formation, associating with AD. Small-molecule GSAP inhibitors are explored to reduce Aβ42; preclinical AD mouse studies show promise for lowering Aβ and improving cognition, with clinical trials early-stage.