GUCY2D

GUCY2D, or guanylate cyclase 2D, is also known as Retinal guanylyl cyclase 1, CORD6, GUC1A4, GUC2D, and ROS-GC.
GUCY2D belongs to the adenylate cyclase class-guanosine cyclase family, which catalyzes the synthesis of cGMP mainly in optic rod and cone cells of the retina, plays a key role in the replenishment of cGMP during phototransduction, and may be involved in the transport of membrane-associated proteins to the outer ganglionic membrane of photoreceptors.
GUCY2D plays a role in cGMP biosynthesis, protein amino acid phosphorylation, receptor guanylyl cyclase signaling pathways, intracellular signaling cascades, visual perception, and responding to stimuli. GUCY2D has been associated with cone optic rod dystrophy type 6 (CORD6) and Leber congenital amaurosis (LCA), which are diseases associated with impaired visual perception.