HCRT

HCRT, also referred to as Orexin or PPOX, emerges from the hypothalamus, primarily produced by neurons in the lateral hypothalamic region. This pivotal brain chemical is vital for the modulation of the sleep-wake cycle, prompting the shift from slumber to wakefulness and sustaining alertness. It acts by binding to HCRT receptors, initiating a cascade of downstream signaling pathways that regulate neuronal excitability and synaptic transmission. HCRT is fundamental to the regulation of sleep patterns, food intake, and autonomic-neuroendocrine functions. Moreover, HCRT deficiencies or malfunctions are closely associated with sleep disorders such as narcolepsy, underscoring its significance in biological and medical research. HCRT represents an important target for investigating the mechanisms of sleep-wake regulation and for the treatment of sleep disorders.