HIPK2

HIPK2, also known as homology domain interaction protein kinase 2, has alternative names including PRO0593 and hHIPk2. HIPK2 is a serine/threonine kinase and a member of the homology domain interaction protein kinase family. HIPK2 interacts with homology domain transcription factors and many other transcription factors (such as p53), serving both as a co-repressor and a co-activator depending on the transcription factor and its subcellular localization. HIPK2 can induce or inhibit transcription, regulating cell differentiation, proliferation, and apoptosis. HIPK2 functions through post-translational modifications such as ubiquitination, sumoylation (SUMO), acetylation, and phosphorylation. HIPK2 promotes apoptosis and acts as a potential tumor suppressor and DNA damage-associated kinase, activating the apoptotic process by phosphorylating different downstream targets. HIPK2 is also involved in tissue and organ formation, as well as tumor development.

Popular Product:

HIPK2 Antibody (CSB-PA867138LA01HU)

Validated Data

IHC image of CSB-PA867138LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA867138LA01HU diluted at 1:500 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The following HIPK2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

HIPK2 Antibodies

HIPK2 Proteins

HIPK2 Antibodies

HIPK2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA867138LA01HU	HIPK2 Antibody	Human	ELISA, IHC
CSB-PA867138LB01HU	HIPK2 Antibody, HRP conjugated	Human	ELISA
CSB-PA867138LC01HU	HIPK2 Antibody, FITC conjugated	Human
CSB-PA867138LD01HU	HIPK2 Antibody, Biotin conjugated	Human	ELISA

HIPK2 Proteins

HIPK2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP867138HU CSB-EP867138HU CSB-BP867138HU CSB-MP867138HU CSB-EP867138HU-B	Recombinant Human Homeodomain-interacting protein kinase 2 (HIPK2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HIPK2 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP882585MO CSB-EP882585MO CSB-BP882585MO CSB-MP882585MO CSB-EP882585MO-B	Recombinant Mouse Homeodomain-interacting protein kinase 2 (Hipk2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HIPK2 Proteins for Mesocricetus auratus (Golden hamster)

Code	Product Name	Source
CSB-YP895752MRG CSB-EP895752MRG CSB-BP895752MRG CSB-MP895752MRG CSB-EP895752MRG-B	Recombinant Mesocricetus auratus Homeodomain-interacting protein kinase 2 (Hipk2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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